Hill A A, Lu J, Masino M A, Olsen O H, Calabrese R L
Biology Department, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
J Comput Neurosci. 2001 May-Jun;10(3):281-302. doi: 10.1023/a:1011216131638.
We modeled a segmental oscillator of the timing network that paces the heartbeat of the leech. This model represents a network of six heart interneurons that comprise the basic rhythm-generating network within a single ganglion. This model builds on a previous two cell model (Nadim et al., 1995) by incorporating modifications of intrinsic and synaptic currents based on the results of a realistic waveform voltage-clamp study (Olsen and Calabrese, 1996). Due to these modifications, the new model behaves more similarly to the biological system than the previous model. For example, the slow-wave oscillation of membrane potential that underlies bursting is similar in form and amplitude to that of the biological system. Furthermore, the new model with its expanded architecture demonstrates how coordinating interneurons contribute to the oscillations within a single ganglion, in addition to their role of intersegmental coordination.
我们构建了一个控制水蛭心跳的定时网络的节段振荡器模型。该模型代表了由六个心脏中间神经元组成的网络，这些神经元构成了单个神经节内的基本节律产生网络。此模型基于先前的双细胞模型（纳迪姆等人，1995年）构建，通过根据实际波形电压钳研究（奥尔森和卡拉布雷斯，1996年）的结果对内在电流和突触电流进行修改。由于这些修改，新模型比先前模型在行为上更类似于生物系统。例如，构成爆发基础的膜电位慢波振荡在形式和幅度上与生物系统的相似。此外，具有扩展架构的新模型展示了协调中间神经元除了其节段间协调作用外，如何对单个神经节内的振荡做出贡献。
