Beyond connectivity of locomotor circuitry-ionic and modulatory mechanisms.

Discrete neural networks in the central nervous system generate the repertoire of motor behavior necessary for animal survival. The final motor output of these networks is the result of the anatomical connectivity between the individual neurons and also their biophysical properties as well as the dynamics of their synaptic transmission. To illustrate how this processing takes place to produce coordinated motor activity, we have summarized some of the results available from the lamprey spinal locomotor network. The detailed knowledge available in this model system on the organization of the network together with the properties of the constituent neurons and the modulatory systems allows us to determine how the impact of specific ion channels and receptors is translated to the global activity of the locomotor circuitry. Understanding the logic of the neuronal and synaptic processing within the locomotor network will provide information about not only their normal operation but also how they react to disruption such as injuries or trauma.