Nardini M, Dijkstra B W
Laboratory of Biophysical Chemistry, BIOSON Research Institute, University of Groningen, Groningen, 9747 AG, The Netherlands.
Curr Opin Struct Biol. 1999 Dec;9(6):732-7. doi: 10.1016/s0959-440x(99)00037-8.
The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.
α/β水解酶折叠是一类蛋白质采用的典型三级折叠结构，这些蛋白质虽无明显的序列相似性，但在进化过程中从一个共同祖先分化而来。最近解析出的结构表明，其折叠结构和底物特异性的变异性显著增加，因此有必要重新定义区分该家族的最小特征。
