Schuler M E, Nair P
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA. mschuler@pediatrics
J Pediatr Psychol. 1999 Dec;24(6):511-4. doi: 10.1093/jpepsy/24.6.511.
To examine the effects of frequency of prenatal maternal cocaine use on infant neurobehavioral outcome beyond the immediate postpartum period, controlling for other substance use.
At 2 weeks postpartum, the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) was administered to infants (N = 55) and their mothers were asked about their prenatal drug use. Mother/infant dyads were placed in one of two groups based on the number of days of reported cocaine use during pregnancy: high frequency (n = 23, > 75th percentile reported days of use) or low frequency (n = 32, < 75th percentile).
Infants in the high frequency cocaine group had worse BNBAS excitability scores than infants in the low frequency cocaine group, when other substance use was controlled statistically.
High frequency of maternal cocaine use during pregnancy is associated with poorer infant neurobehavioral outcome beyond the early postpartum period, when other substance use is controlled.
在控制其他物质使用的情况下，研究产前母亲使用可卡因的频率对产后早期以外婴儿神经行为结局的影响。
产后2周时，对55名婴儿进行了布雷泽尔顿新生儿行为评估量表（BNBAS）测试，并询问其母亲产前的药物使用情况。根据孕期报告的可卡因使用天数，母婴二元组被分为两组之一：高频组（n = 23，使用天数报告在第75百分位数以上）或低频组（n = 32，使用天数报告在第75百分位数以下）。
在对其他物质使用进行统计学控制后，高频可卡因组婴儿的BNBAS兴奋性得分低于低频可卡因组婴儿。
在控制其他物质使用的情况下，孕期母亲高频使用可卡因与产后早期以外较差的婴儿神经行为结局相关。
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