Reed S F, Porges S W, Newlin D B
Department of Human Development, University of Maryland, USA.
Exp Clin Psychopharmacol. 1999 Nov;7(4):484-92. doi: 10.1037//1064-1297.7.4.484.
Research was conducted to evaluate the influence of acute alcohol consumption on vagal regulation of heart rate. Nine men with histories of polydrug use participated in this residential study. On 5 separate days, they drank liquids consisting of cold water (on 2 days), a moderate dose of alcohol (0.64 g/kg), a high dose of alcohol (1.12 g/kg), and a placebo. Continuous recordings of heart period were quantified to produce 3 measures of heart rate variability, reflecting the amplitude of 3 neurophysiologically mediated rhythms. Heart period, respiratory rhythm (i.e., respiratory sinus arrhythmia [RSA]), and the 0.064-0.10-Hz vasomotor rhythm were significantly lower during the high alcohol dose condition, relative to the placebo and water conditions. Because the neural regulation of the heart by the vagus contributes to these variables, these findings suggest that alcohol reduces cardiac vagal tone. In support of this explanation, alcohol also decreased the coupling between changes in heart period and changes in RSA. This study demonstrated that alcohol produces a dysregulated state in which heart rate is relatively uncoupled from vagal activity.
开展了一项研究，以评估急性饮酒对心率迷走神经调节的影响。九名有多种药物使用史的男性参与了这项住院研究。在5个不同的日子里，他们饮用了由冷水（2天）、中等剂量酒精（0.64克/千克）、高剂量酒精（1.12克/千克）和安慰剂组成的液体。对心动周期进行连续记录，以量化产生3种心率变异性测量指标，反映3种神经生理学介导节律的幅度。相对于安慰剂和水的情况，在高酒精剂量条件下，心动周期、呼吸节律（即呼吸性窦性心律不齐[RSA]）和0.064 - 0.10赫兹血管运动节律显著降低。由于迷走神经对心脏的神经调节作用于这些变量，这些发现表明酒精会降低心脏迷走神经张力。为支持这一解释，酒精还降低了心动周期变化与RSA变化之间的耦合。这项研究表明，酒精会产生一种调节失调的状态，即心率与迷走神经活动相对解耦。
