İzci Filiz, Ünübol Başak, İzci Servet
Department of Psychiatry, Erenköy Mental and Nervous Diseases Training and Research Hospital, İstanbul, Turkey.
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
Psychiatry Clin Psychopharmacol. 2023 Dec 1;33(4):280-286. doi: 10.5152/pcp.2023.22537. eCollection 2023 Dec.
Our study aimed to examine the possible risk of ventricular arrhythmia and sudden cardiac death by calculating the electrocardiographic changes and indicators of ventricular repolarization during and after alcohol withdrawal.
One hundred participants who were identified with alcohol withdrawal and who met the inclusion criteria were included in the study. Data were collected between July 2020 and August 2020. The distance interval between Q and T waves, corrected distance interval between Q and T waves, T peak/distance interval between Q and T waves, and T peak/corrected distance interval between Q and T waves interval ratios ratios were measured in 12-lead electrocardiographic measurements during the withdrawal period and after withdrawal symptoms subsided in patients with a Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised score >7 and a Framingham heart risk score <10%.
There was a significant difference between the patient's heart rate, distance interval between Q and T waves, corrected distance interval between Q and T waves interval, and T peak/distance interval between Q and T waves values during withdrawal (input) and after alcohol withdrawal (output) (05). The mean corrected distance interval between Q and T waves interval input value (433.63 ± 17.79) is significantly different and higher than the output value of the mean corrected distance interval between Q and T waves (420.67 ± 13.78) (05). Similarly, the mean T peak input value (81.36 ± 5.90) is significantly different and higher than the mean T peak output value (79.94 ± 5.39) (05) and the mean T peak/input value of the distance interval between Q and T waves (0.222 ± 0.00) than the mean T peak / output value of the distance interval between Q and T waves (0.214 ± 0.00) (001).
These consequences suggest the risk for an accelerated hazard of ventricular arrhythmias in participants with alcohol withdrawal. Significantly, considering the improvement of the electrocardiographic changes of the patients after terminating alcohol intake, a possible cardiac arrhythmia may be more common during this period. Close monitoring of electrocardiograms and timely withdrawal treatment can prevent life-threatening arrhythmias in alcohol withdrawal patients.
我们的研究旨在通过计算戒酒期间及戒酒后的心电图变化和心室复极指标，来检测室性心律失常和心源性猝死的潜在风险。
本研究纳入了100名确诊为戒酒且符合纳入标准的参与者。数据收集于2020年7月至2020年8月期间。对酒精戒断评估量表修订版评分>7且弗雷明汉心脏风险评分<10%的患者，在戒断期及戒断症状消退后进行12导联心电图测量，测量Q波与T波之间的距离间期、校正后的Q波与T波之间的距离间期、T波峰值/Q波与T波之间的距离间期以及T波峰值/校正后的Q波与T波之间的距离间期比值。
患者在戒断期（输入）和戒酒后（输出）的心率、Q波与T波之间的距离间期、校正后的Q波与T波之间的距离间期以及T波峰值/Q波与T波之间的距离间期值存在显著差异（P<0.05）。校正后的Q波与T波之间的距离间期输入值的平均值（433.63±17.79）与校正后的Q波与T波之间的距离间期输出值的平均值（420.67±13.78）相比有显著差异且更高（P<0.05）。同样，T波峰值输入值的平均值（81.36±5.90）与T波峰值输出值的平均值（79.94±5.39）相比有显著差异且更高（P<0.05），且T波峰值/Q波与T波之间的距离间期输入值的平均值（0.222±0.00）比T波峰值/Q波与T波之间的距离间期输出值的平均值（0.214±0.00）更高（P<0.001）。
这些结果表明，戒酒参与者发生室性心律失常加速风险的可能性。重要的是，考虑到戒酒患者在停止饮酒后心电图变化有所改善，在此期间可能更易出现心律失常。密切监测心电图并及时进行戒断治疗可预防戒酒患者发生危及生命的心律失常。
