Llinás R R, Ribary U, Jeanmonod D, Kronberg E, Mitra P P
Department of Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15222-7. doi: 10.1073/pnas.96.26.15222.
Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency theta rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent theta activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic gamma-band activation, which we refer to as the "edge effect." This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry between high- and low-frequency thalamocortical modules at the cortical level.
在清醒的健康人类对照者以及患有神经源性疼痛、耳鸣、帕金森病或抑郁症的患者中记录了自发性脑磁图活动。与对照者相比，患者表现出低频θ节律增加，同时高频和低频振荡之间的相关性广泛且显著增加。这些数据表明存在丘脑皮质节律紊乱，我们认为这是上述所有病症的病因。这种相干的θ活动是丘脑与皮质之间共振相互作用的结果，是由丘脑细胞产生的低阈值钙棘波爆发引起的。这些爆发的存在与丘脑细胞超极化直接相关，丘脑细胞超极化是由过度抑制或去易化导致的。阳性临床症状的出现被认为是由异位γ波段激活引起的，我们将其称为“边缘效应”。这种效应表现为低频和高频振荡之间的相关性增加，这可能是由于皮质水平上高频和低频丘脑皮质模块之间的抑制不对称所致。
