• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

帕金森病。两部分中的第二部分。

Parkinson's disease. Second of two parts.

作者信息

Lang A E, Lozano A M

机构信息

Department of Medicine, University of Toronto and the Toronto Hospital, Canada.

出版信息

N Engl J Med. 1998 Oct 15;339(16):1130-43. doi: 10.1056/NEJM199810153391607.

DOI:10.1056/NEJM199810153391607
PMID:9770561
Abstract

At no time in the past have the basic and clinical sciences applied to Parkinson's disease been so active. Experimental therapies under study at present promise to improve on the limitations of existing treatments. Future progress in understanding the causation and pathogenesis of the disorder will permit the development of new treatments that will slow, halt, or even reverse the currently inexorable progressive course of Parkinson's disease.

摘要

在过去,应用于帕金森病的基础科学和临床科学从未像现在这样活跃。目前正在研究的实验性疗法有望改善现有治疗方法的局限性。未来在了解该疾病的病因和发病机制方面取得的进展将促使开发出新的治疗方法,这些方法将减缓、阻止甚至逆转目前帕金森病不可阻挡的进展过程。

相似文献

1
Parkinson's disease. Second of two parts.帕金森病。两部分中的第二部分。
N Engl J Med. 1998 Oct 15;339(16):1130-43. doi: 10.1056/NEJM199810153391607.
2
Effective strategies in the management of Parkinson's disease.帕金森病管理中的有效策略。
Hosp Med. 1998 Apr;59(4):287-90.
3
Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease.多巴胺能对认知功能的调节——对帕金森病左旋多巴治疗的启示
Neurosci Biobehav Rev. 2006;30(1):1-23. doi: 10.1016/j.neubiorev.2005.03.024. Epub 2005 Jun 1.
4
Levodopa therapeutics for Parkinson's disease: new developments.帕金森病的左旋多巴疗法:新进展
Parkinsonism Relat Disord. 2009 Jan;15 Suppl 1:S31-4. doi: 10.1016/S1353-8020(09)70009-4.
5
[Updates in practical neurology--I. The principles of modern levodopa therapy in Parkinson's disease].[实用神经病学进展——I.帕金森病现代左旋多巴治疗的原则]
Ideggyogy Sz. 2007 Jan 20;60(1-2):61-4.
6
[Pharmacological therapy of complicated Parkinson's disease].[复杂帕金森病的药物治疗]
Rev Neurol. 1997 Aug;25 Suppl 2:S170-9.
7
Levodopa therapy for Parkinson's disease: challenges and future prospects.帕金森病的左旋多巴治疗:挑战与未来展望。
Mov Disord. 2008;23 Suppl 3:S495-6. doi: 10.1002/mds.22048.
8
Moderate Parkinson's disease. Strategies for maximizing treatment.中度帕金森病。优化治疗的策略。
Postgrad Med. 1996 Jan;99(1):52-4, 61-3, 67-8, passim.
9
Treatment of Parkinson's disease.帕金森病的治疗。
Aust Fam Physician. 1995 Sep;24(9):1685-7, 1690-2.
10
Recent advances in pharmacological therapy of Parkinson's disease.帕金森病药物治疗的最新进展
Adv Neurol. 1993;60:626-35.

引用本文的文献

1
Towards scalable screening for the early detection of Parkinson's disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker.迈向可扩展的帕金森病早期检测筛查:基于iPad的眼动评估系统与临床级眼动追踪仪的验证
NPJ Parkinsons Dis. 2025 Aug 8;11(1):233. doi: 10.1038/s41531-025-01079-9.
2
A domain-based framework for cognitive profile identification in Parkinson's disease across diverse samples.一种基于领域的框架,用于跨不同样本识别帕金森病的认知概况。
Front Neuroanat. 2025 Jun 19;19:1566835. doi: 10.3389/fnana.2025.1566835. eCollection 2025.
3
Role of Cellular Senescence in Parkinson's Disease: Potential for Disease-Modification Through Senotherapy.
细胞衰老在帕金森病中的作用:通过衰老疗法进行疾病修饰的潜力。
Biomedicines. 2025 Jun 7;13(6):1400. doi: 10.3390/biomedicines13061400.
4
Learning to suppress tremors: a deep reinforcement learning-enabled soft exoskeleton for Parkinson's patients.学习抑制震颤:一种用于帕金森病患者的基于深度强化学习的软外骨骼
Front Robot AI. 2025 May 21;12:1537470. doi: 10.3389/frobt.2025.1537470. eCollection 2025.
5
Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders.单胺信号传导与神经炎症:机制联系及其对神经精神疾病的影响
Front Immunol. 2025 Apr 28;16:1543730. doi: 10.3389/fimmu.2025.1543730. eCollection 2025.
6
Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease.多巴胺能调节及其剂量对帕金森病脑状态动力学和工作记忆组成过程的影响。
Nat Commun. 2025 Mar 11;16(1):2433. doi: 10.1038/s41467-025-56660-w.
7
The feasibility of a self-regulation and mental imagery programme to enhance everyday functioning for people with Parkinson's disease: study protocol.一项自我调节与心理意象计划对改善帕金森病患者日常功能的可行性:研究方案
Pilot Feasibility Stud. 2024 Dec 5;10(1):148. doi: 10.1186/s40814-024-01578-1.
8
Why does invasive brain stimulation sometimes improve memory and sometimes impair it?为什么侵入性脑刺激有时能改善记忆,有时却会损害记忆?
PLoS Biol. 2024 Oct 25;22(10):e3002894. doi: 10.1371/journal.pbio.3002894. eCollection 2024 Oct.
9
Functional and free-water imaging in rapid eye movement behaviour disorder and Parkinson's disease.快速眼动行为障碍和帕金森病中的功能及自由水成像
Brain Commun. 2024 Oct 10;6(5):fcae344. doi: 10.1093/braincomms/fcae344. eCollection 2024.
10
A Comprehensive Review on Repurposing the Nanocarriers for the Treatment of Parkinson's Disease: An Updated Patent and Clinical Trials.纳米载体用于治疗帕金森病的再利用综合综述:最新专利与临床试验
CNS Neurol Disord Drug Targets. 2025;24(3):181-195. doi: 10.2174/0118715273323074241001071645.