Howard C J, Brooke G P, Werling D, Sopp P, Hope J C, Parsons K R, Collins R A
Institute for Animal Health, Compton, Newbury, UK.
Vet Immunol Immunopathol. 1999 Dec 15;72(1-2):119-24. doi: 10.1016/s0165-2427(99)00124-5.
Dendritic cells are professional antigen presenting cells derived from the bone marrow and distributed throughout body tissues where they are located in sites that are suitable for antigen uptake. They are central to the induction of immune responses in naive animals and thus have become targets in strategies that are aimed at modulating resistance to infection. Studies in cattle have shown that the dendritic cells are phenotypically heterogeneous and that the different phenotypes have different biological properties. The molecular basis for this variation has begun to be investigated and has led to the identification of a member of the SIRPalpha family of signal regulatory proteins (MyD1) on a subset of dendritic cells in afferent lymph. Uptake of antigen by cattle dendritic cells is by a number of mechanisms that can involve endocytosis via clathrin coated pits or via caveolae as well as macropinocytosis.
树突状细胞是源自骨髓的专职抗原呈递细胞，分布于全身组织中适合摄取抗原的部位。它们在幼稚动物免疫反应的诱导中起核心作用，因此已成为旨在调节抗感染能力的策略中的靶点。对牛的研究表明，树突状细胞在表型上具有异质性，不同的表型具有不同的生物学特性。这种变异的分子基础已开始被研究，并导致在传入淋巴中的一部分树突状细胞上鉴定出信号调节蛋白SIRPα家族的一个成员（MyD1）。牛树突状细胞摄取抗原的方式有多种机制，可通过网格蛋白包被小窝或小窝进行内吞作用，也可通过巨胞饮作用。
