Norbury Christopher C
Department of Microbiology and Immunology, Penn State M.S. Hershey College of Medicine, Hershey, PA 17033, USA.
Immunology. 2006 Apr;117(4):443-51. doi: 10.1111/j.1365-2567.2006.02335.x.
Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocytic pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo.
巨吞饮作用是一种依赖肌动蛋白形成大囊泡的过程,这些大囊泡能够使大量液相溶质内化。在大多数被检测的细胞中,需要外源性刺激来启动这种内吞途径。然而,树突状细胞被认为作为其哨兵功能的一部分,可组成性地大量巨吞饮外源性溶质。在这篇综述中,我们讨论了树突状细胞巨吞饮外源性溶质并随后将内化物质衍生的抗原肽呈递给T细胞的证据。此外,我们将这些数据置于体内免疫监视的背景中。