一些植物源性降血糖药物的比较评价。

A comparative evaluation of some blood sugar lowering agents of plant origin.

作者信息

Chattopadhyay R R

机构信息

Biometry Research Unit, Indian Statistical Institute, Calcutta.

出版信息

J Ethnopharmacol. 1999 Nov 30;67(3):367-72. doi: 10.1016/s0378-8741(99)00095-1.

DOI:10.1016/s0378-8741(99)00095-1

PMID:10617074

Abstract

A comparison of blood sugar lowering activity of four important medicinal plants (Azadirachta indica, Gymnema sylvestre, Catharanthus roseus and Ocimum sanctum) were carried out against normal and streptozotocin-induced diabetic rat models. The plant extracts decreased the blood sugar level in varying degrees. Blood sugar lowering unit (BLU) of activity of each leaf extract and tolbutamide was calculated by ED50 values. Statistical analysis revealed significant (P < 0.05) variation among the treatments as well as doses with regard to their blood sugar lowering capacity. A. indica leaf extract was found to have the most potent blood sugar-lowering activity followed by C. roseus, G. sylvestre and O. sanctum.

摘要

对四种重要药用植物（印楝、匙羹藤、长春花和神圣罗勒）针对正常和链脲佐菌素诱导的糖尿病大鼠模型的降血糖活性进行了比较。植物提取物不同程度地降低了血糖水平。通过半数有效剂量（ED50）值计算每种叶提取物和甲苯磺丁脲的降血糖活性单位（BLU）。统计分析表明，各处理组及其剂量在降血糖能力方面存在显著差异（P < 0.05）。发现印楝叶提取物具有最有效的降血糖活性，其次是长春花、匙羹藤和神圣罗勒。