Pinto-Martin J A, Whitaker A H, Feldman J F, Van Rossem R, Paneth N
School of Nursing and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia 19104, USA.
Dev Med Child Neurol. 1999 Dec;41(12):826-33. doi: 10.1017/s0012162299001644.
This study sought to determine whether neonatal cranial ultrasound abnormalities are related to motor and cognitive outcomes in low-birthweight (LBW, <2000 g) children without major motor or cognitive disability. The relation of neonatal cranial ultrasound abnormalities to motor performance and general cognitive ability at ages 2, 6, and 9 years was examined in a prospectively followed regional cohort of LBW children, excluding those with major disability, and controlling for other risk factors. Compared with children without ultrasound abnormalities, children with abnormalities indicative of ischemic white-matter injury had poorer motor performance at all three ages and, at age 2, lower general cognitive ability. The latter finding was not seen when motor performance was also controlled for. It was concluded that in LBW children without major motor or cognitive disability, ischemic white-matter injury indicated by neonatal cranial ultrasound abnormalities adversely affected motor performance at ages 2, 6, and 9 years, but not general cognitive ability.
本研究旨在确定新生儿颅脑超声异常是否与出生体重低（LBW，<2000 g）且无严重运动或认知障碍的儿童的运动和认知结局相关。在一个前瞻性随访的出生体重低儿童区域队列中，排除有严重残疾的儿童，并控制其他风险因素，研究了新生儿颅脑超声异常与2岁、6岁和9岁时运动表现及一般认知能力的关系。与无超声异常的儿童相比，有缺血性白质损伤迹象的超声异常儿童在所有三个年龄段的运动表现均较差，且在2岁时一般认知能力较低。当对运动表现进行控制时，未发现后一结果。研究得出结论，在无严重运动或认知障碍的出生体重低儿童中，新生儿颅脑超声异常所提示的缺血性白质损伤对2岁、6岁和9岁时的运动表现有不利影响，但对一般认知能力无影响。
