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ETYA和BW 755c对豚鼠离体气管中花生四烯酸诱导收缩的影响。

Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.

作者信息

Mitchell H W

出版信息

Br J Pharmacol. 1982 Aug;76(4):527-9. doi: 10.1111/j.1476-5381.1982.tb09250.x.

DOI:10.1111/j.1476-5381.1982.tb09250.x
PMID:6809090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071828/
Abstract
  1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induced responses. Likewise BW 755c (113 micro M) reversed the effect of indomethacin. 4. The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.
摘要
  1. 花生四烯酸对吲哚美辛处理过的豚鼠气管所引起的收缩作用，比对对照气管的收缩作用更大。2. 用5,8,11,14-二十碳四烯炔酸（ETYA，10微摩尔）处理的气管，其收缩没有变化。3. ETYA（100微摩尔）阻断了吲哚美辛对花生四烯酸诱导反应的作用。同样，BW 755c（113微摩尔）逆转了吲哚美辛的作用。4. 结果表明，花生四烯酸脂氧合酶产物可能是在吲哚美辛存在的情况下所观察到的收缩反应的原因。

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Mediators of arachidonic acid-induced contractions of indomethacin-treated guinea-pig airways: leukotrienes C4 and D4.花生四烯酸诱导消炎痛处理的豚鼠气道收缩的介质：白三烯C4和D4。
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本文引用的文献

1
The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs.豚鼠离体气管和肺条制备物中花生四烯酸的代谢
Lung. 1980;158(3):121-9. doi: 10.1007/BF02713714.
2
The effect of inhibitors of arachidonic acid metabolism on drug-induced contractions in isolated tracheal smooth muscle of the pig.花生四烯酸代谢抑制剂对猪离体气管平滑肌药物诱导收缩的影响。
Br J Pharmacol. 1982 Jan;75(1):129-36. doi: 10.1111/j.1476-5381.1982.tb08765.x.
3
A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.脂氧合酶产物作为气道平滑肌反应性调节剂的潜在作用。
Br J Pharmacol. 1980 Jun;69(2):167-9. doi: 10.1111/j.1476-5381.1980.tb07886.x.
4
Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.脂氧合酶途径参与过敏性气管收缩的证据。
Prostaglandins. 1980 Apr;19(4):499-515. doi: 10.1016/s0090-6980(80)80001-3.
5
Enzyme inhibition by acetylenic compounds.炔属化合物对酶的抑制作用。
Biochem Biophys Res Commun. 1970 Jul 13;40(1):218-23. doi: 10.1016/0006-291x(70)91069-7.
6
Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.豚鼠气管体外收缩反应：前列腺素合成抑制药物的影响
J Pharmacol Exp Ther. 1975 Sep;194(3):554-64.
7
On the formation of thromboxane B2 and 12l-hydroxy-5,8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pig.豚鼠组织中血栓素B2和12-羟基-5,8,10,14-二十碳四烯酸（12-HETE）的形成
Biochim Biophys Acta. 1976 Jun 22;431(3):651-4. doi: 10.1016/0005-2760(76)90232-0.
8
Anaphylaxis in guinea-pig peripheral airways in vitro.豚鼠外周气道体外过敏反应
Eur J Pharmacol. 1979 Feb 15;54(1-2):69-78. doi: 10.1016/0014-2999(79)90409-6.
9
Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis.非甾体抗炎药超敏反应的临床模式及其发病机制。
J Allergy Clin Immunol. 1977 Nov;60(5):276-84. doi: 10.1016/0091-6749(77)90106-3.
10
The effects of arachidonic acid, indomethacin and SC-19220 on guinea-pig tracheal muscle tone.花生四烯酸、吲哚美辛和SC - 19220对豚鼠气管肌张力的影响。
Eur J Pharmacol. 1975 Feb;30(2):148-53. doi: 10.1016/0014-2999(75)90093-x.