ETYA和BW 755c对豚鼠离体气管中花生四烯酸诱导收缩的影响。
Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.
作者信息
Mitchell H W
出版信息
Br J Pharmacol. 1982 Aug;76(4):527-9. doi: 10.1111/j.1476-5381.1982.tb09250.x.
Abstract
- Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induced responses. Likewise BW 755c (113 micro M) reversed the effect of indomethacin. 4. The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.
摘要
- 花生四烯酸对吲哚美辛处理过的豚鼠气管所引起的收缩作用，比对对照气管的收缩作用更大。2. 用5,8,11,14-二十碳四烯炔酸（ETYA，10微摩尔）处理的气管，其收缩没有变化。3. ETYA（100微摩尔）阻断了吲哚美辛对花生四烯酸诱导反应的作用。同样，BW 755c（113微摩尔）逆转了吲哚美辛的作用。4. 结果表明，花生四烯酸脂氧合酶产物可能是在吲哚美辛存在的情况下所观察到的收缩反应的原因。
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