Antoine J C, Honnorat J, Anterion C T, Aguera M, Absi L, Fournel P, Michel D
Department of Neurology, Hôpital de Bellevue, Saint Etienne, France.
J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):706-10. doi: 10.1136/jnnp.58.6.706.
Two patients with clinical and radiological evidence of limbic encephalitis associated with an invasive lymphoepithelial thymoma who improved after thymectomy and radiotherapy are reported. The serum of both patients and the CSF of one of them contained different types of antibodies that immunoreacted with human and rat brain and newborn rat thymus. After treatment of the tumour, the antibody titres decreased. Similar antibodies were not found in various controls. Two out of 16 patients with thymoma, myasthenia gravis, and no CNS involvement had low titres of antibodies reacting with the brain. It is suggested that in some patients with thymoma, an autoimmune reaction involving antigens common to the brain and thymus is possibly misdirected against the CNS.
报道了两名患有与侵袭性淋巴上皮性胸腺瘤相关的边缘叶脑炎的患者，他们在胸腺切除和放疗后病情有所改善。两名患者的血清以及其中一名患者的脑脊液中含有不同类型的抗体，这些抗体与人和大鼠脑以及新生大鼠胸腺发生免疫反应。肿瘤治疗后，抗体滴度下降。在各种对照中未发现类似抗体。16名患有胸腺瘤、重症肌无力且无中枢神经系统受累的患者中有两名抗体与脑反应的滴度较低。提示在一些胸腺瘤患者中，涉及脑和胸腺共同抗原的自身免疫反应可能错误地针对中枢神经系统。
