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针对胰岛素受体的自身抗体可激活大鼠脂肪细胞中的糖原合酶。

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes.

作者信息

Lawrence J C, Larner J, Kahn C R, Roth J

出版信息

Mol Cell Biochem. 1978 Dec 22;22(2-3):153-7. doi: 10.1007/BF00496241.

DOI:10.1007/BF00496241
PMID:106236
Abstract

Autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. The interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses.

摘要

胰岛素受体自身抗体可模拟胰岛素对糖原合酶和磷酸化酶的作用。抗体与脂肪细胞表面胰岛素受体的相互作用似乎足以促进这些细胞内酶活性的稳定变化，这表明胰岛素的内化或加工在这些生物学反应的产生中并不重要。

相似文献

1
Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes.针对胰岛素受体的自身抗体可激活大鼠脂肪细胞中的糖原合酶。
Mol Cell Biochem. 1978 Dec 22;22(2-3):153-7. doi: 10.1007/BF00496241.
2
Activation of glycogen synthase in rat adipocytes by insulin and glucose involves increased glucose transport and phosphorylation.
J Biol Chem. 1978 Apr 10;253(7):2104-13.
3
Control of glycogen synthase and phosphorylase by insulin in rat adipocytes which is unrelated to the concentration of cyclic AMP.胰岛素对大鼠脂肪细胞中糖原合酶和磷酸化酶的调控与环磷酸腺苷浓度无关。
Biochim Biophys Acta. 1979 Feb 1;582(3):402-1. doi: 10.1016/0304-4165(79)90132-6.
4
A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.钒酸盐对大鼠脂肪细胞糖原合酶的胰岛素样作用的新机制。
J Biol Chem. 1984 May 25;259(10):6650-8.
5
Short-term stimulation by adenosine of basal and insulin-induced glycogen synthesis in rat adipose tissue.
Biochim Biophys Acta. 1986 Jan 23;885(1):43-8. doi: 10.1016/0167-4889(86)90036-4.
6
Insulin regulation of hepatic glycogen synthase and phosphorylase.胰岛素对肝糖原合酶和磷酸化酶的调节。
Biochemistry. 1978 Feb 7;17(3):406-10. doi: 10.1021/bi00596a004.
7
Effect of cytochalasin B and D on groups of insulin receptors and on insulin action in rat adipocytes. Possible evidence for a structural relationship of the insulin receptor to the glucose transport system.细胞松弛素B和D对大鼠脂肪细胞中胰岛素受体群体及胰岛素作用的影响。胰岛素受体与葡萄糖转运系统结构关系的可能证据。
J Clin Invest. 1979 Apr;63(4):571-9. doi: 10.1172/JCI109338.
8
Activation of phosphoprotein phosphatases by growth hormone sequences with insulin-like activity.具有胰岛素样活性的生长激素序列对磷蛋白磷酸酶的激活作用。
Mol Cell Biochem. 1987 Mar;74(1):95-101. doi: 10.1007/BF00221916.
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Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin receptor.钒酸盐对脂肪细胞糖原合酶及胰岛素受体95000道尔顿亚基磷酸化的胰岛素样作用。
Biochem Biophys Res Commun. 1983 May 31;113(1):80-6. doi: 10.1016/0006-291x(83)90434-5.
10
Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells.胰岛素对H4肝癌细胞中糖原代谢酶的长期调节作用。
Mol Cell Biochem. 1987 Jun;75(2):137-49. doi: 10.1007/BF00229902.

引用本文的文献

1
Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.抗体诱导的胰岛素受体脱敏。3T3-L1脂肪成纤维细胞中脱敏机制的研究。
J Clin Invest. 1980 Nov;66(5):1124-34. doi: 10.1172/JCI109942.
2
Chemical mechanism of insulin action via proteolytic formation of mediator peptides.胰岛素通过介导肽的蛋白水解形成发挥作用的化学机制。
Mol Cell Biochem. 1981 Nov 13;40(3):155-61. doi: 10.1007/BF00224609.
3
Independent control of selected insulin-sensitive cell membrane and intracellular functions-the linkage of cell membrane and intracellular events controlled by insulin. III. The influence of trypsin on cell membrane hexose transport and on glycogen synthase and mitochondrial pyruvate dehydrogenase activation.

本文引用的文献

1
Role of cyclic-3',5'-amp in the response of adipose tissue to insulin.环3',5'-腺苷酸在脂肪组织对胰岛素反应中的作用。
Proc Natl Acad Sci U S A. 1966 Aug;56(2):757-63. doi: 10.1073/pnas.56.2.757.
2
Interaction of insulin with the cell membrane: the primary action of insulin.胰岛素与细胞膜的相互作用：胰岛素的主要作用。
Proc Natl Acad Sci U S A. 1969 Jun;63(2):450-7. doi: 10.1073/pnas.63.2.450.
3
Structure and activity of insulin. XI. Biologically active synthetic peptides of the insulin sequence B22-25.胰岛素的结构与活性。XI. 胰岛素序列B22 - 25的生物活性合成肽。
对选定的胰岛素敏感细胞膜和细胞内功能的独立控制——胰岛素控制的细胞膜与细胞内事件的联系。III. 胰蛋白酶对细胞膜己糖转运、糖原合酶及线粒体丙酮酸脱氢酶激活的影响。
Mol Cell Biochem. 1981 Jul 7;37(2):125-30. doi: 10.1007/BF02354936.
4
Independent control of selected insulin-sensitive cell membrane and intracellular functions - the linkage of cell membrane and intracellular events controlled by insulin. L. The influence of pH on insulin binding, membrane hexose transport and glycogen synthase activation.对选定的胰岛素敏感细胞膜及细胞内功能的独立控制——胰岛素所控制的细胞膜与细胞内事件的联系。L. pH对胰岛素结合、膜己糖转运及糖原合酶激活的影响。
Mol Cell Biochem. 1981 Jul 7;37(2):109-15. doi: 10.1007/BF02354934.
5
Hepatic effects of glucose and insulin independent of cyclic nucleotide changes.葡萄糖和胰岛素的肝脏效应独立于环核苷酸变化。
Acta Diabetol Lat. 1981 Oct-Dec;18(4):297-310. doi: 10.1007/BF02042813.
6
A partial view of the mechanism of insulin action.胰岛素作用机制的部分观点。
Diabetologia. 1981 Oct;21(4):347-62. doi: 10.1007/BF00252681.
7
The role of the insulin receptor in mediating the insulin-stimulated growth response in Reuber H-35 cells.胰岛素受体在介导鲁伯H-35细胞中胰岛素刺激的生长反应中的作用。
Mol Cell Biochem. 1984;58(1-2):139-46. doi: 10.1007/BF00240613.
8
Anti-insulin receptor antibodies mimic the effects of insulin on the activities of pyruvate dehydrogenase and acetylCoA carboxylase and on specific protein phosphorylation in rat epididymal fat cells.抗胰岛素受体抗体可模拟胰岛素对大鼠附睾脂肪细胞中丙酮酸脱氢酶和乙酰辅酶A羧化酶活性以及特定蛋白质磷酸化的作用。
Diabetologia. 1980 Apr;18(4):307-12. doi: 10.1007/BF00251011.
Hoppe Seylers Z Physiol Chem. 1971 Dec;352(12):1735-8.
4
The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells.脂肪细胞的胰岛素结合能力与细胞对胰岛素的反应之间的关系。对完整脂肪细胞和经胰蛋白酶处理的脂肪细胞的研究。
J Biol Chem. 1971 Oct 25;246(20):6210-6.
5
Structure and activity of insulin. XII. Further studies on biologically acitve synthetic fragments of the B-chain.胰岛素的结构与活性。十二。对B链生物活性合成片段的进一步研究。
Hoppe Seylers Z Physiol Chem. 1973 Mar;354(3):321-30. doi: 10.1515/bchm2.1973.354.1.321.
6
Biological activity of insulin-sepharose?胰岛素琼脂糖凝胶的生物活性？
Science. 1973 Mar 16;179(4078):1142-4. doi: 10.1126/science.179.4078.1142.
7
Insulin binding to rat liver Golgi fractions.胰岛素与大鼠肝脏高尔基体组分的结合。
J Cell Biol. 1973 Dec;59(3):771-6. doi: 10.1083/jcb.59.3.771.
8
Hormonal regulation of adipocyte enzymes. The effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase, and glycogen synthase.脂肪细胞酶的激素调节。肾上腺素和胰岛素对脂肪酶、磷酸化酶激酶、磷酸化酶和糖原合酶的调控作用。
J Biol Chem. 1973 Jun 10;248(11):3823-30.
9
Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.利用抗胰岛素受体的125I标记自身抗体检测和鉴定胰岛素细胞表面受体的直接方法。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4115-9. doi: 10.1073/pnas.73.11.4115.
10
Re-evaluation of Sepharose-insulin as a tool for the study of insulin action.对琼脂糖胰岛素作为胰岛素作用研究工具的重新评估。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):248-52. doi: 10.1073/pnas.72.1.248.