来自粉防己、无柄花耳草、山榄仁树和暹罗九里香的抗疟药。

Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis.

作者信息

Likhitwitayawuid K, Dej-adisai S, Jongbunprasert V, Krungkrai J

出版信息

Planta Med. 1999 Dec;65(8):754-6. doi: 10.1055/s-2006-960858.

DOI:10.1055/s-2006-960858

Abstract

Fourteen compounds isolated from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis were tested for their antimalarial potential. The 6a,7-dehydroaporphine alkaloids dehydrostephanine and dehydrocrebanine showed potent activity with IC50 values of 40 and 70 ng/ml, respectively. The 13C-NMR data of rubiadin, rubiadin-1-methyl ether, diospyrin and 5-hydroxy-4-methoxy-2-naphthal-dehyde were extensively studied.

摘要

对从毛叶轮环藤、无柄花棱柱木、山榄仁树和暹罗九里香中分离出的14种化合物进行了抗疟潜力测试。6a,7-脱氢阿朴啡生物碱去氢千金藤碱和去氢克班宁表现出强效活性，IC50值分别为40和70纳克/毫升。对茜草素、茜草素-1-甲醚、柿黄素和5-羟基-4-甲氧基-2-萘甲醛的13C核磁共振数据进行了广泛研究。