自身免疫中的凋亡和效应途径。

Apoptotic and effector pathways in autoimmunity.

作者信息

Chervonsky A V

机构信息

Jackson Laboratory, Bar Harbor, ME 04609, USA.

出版信息

Curr Opin Immunol. 1999 Dec;11(6):684-8. doi: 10.1016/s0952-7915(99)00037-0.

DOI:10.1016/s0952-7915(99)00037-0

PMID:10631555

Abstract

Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues.

摘要

程序性细胞死亡是一种重要的抗自身免疫机制，用于清除自身反应性淋巴细胞，并限制病毒感染以及免疫反应所导致的组织损伤的扩散。然而，在自身免疫性疾病中，通过与正常免疫反应相似的效应机制激活程序性细胞死亡会导致靶组织的破坏加剧。