Olajide O A, Awe S O, Makinde J M, Morebise O
Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Pharm Pharmacol. 1999 Nov;51(11):1321-4. doi: 10.1211/0022357991776903.
The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg(-1) of the extract at 4 h was 42.5 +/- 0.4 mg/100 mL (control 67.4 +/- 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg(-1) extract fell to 51.9 +/- 1.2, 47.3 +/- 0.8, 43.1 +/- 0.4 and 40.0 +/- 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg(-1) extract-treated animals having a plasma glucose level of 248.7 +/- 5.3 mg/100 mL compared with glibenclamide (10 mg kg(-1))-treated animals with a plasma glucose level of 251.5 +/- 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.
对巴戟天（茜草科）叶甲醇提取物在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中的降血糖和抗高血糖活性进行了研究。在正常大鼠中，口服给药后4小时内，提取物表现出显著的（P < 0.05）剂量依赖性降血糖活性。提取物400 mg kg(-1)剂量组在4小时时的血浆葡萄糖水平为42.5 +/- 0.4 mg/100 mL（对照组为67.4 +/- 1.2 mg/100 mL）。12小时后，给予50、100、200或400 mg kg(-1)提取物的大鼠血浆葡萄糖水平分别降至51.9 +/- 1.2、47.3 +/- 0.8、43.1 +/- 0.4和40.0 +/- 0.5 mg/100 mL。在高血糖大鼠中，口服给药后第3天，提取物产生了显著的（P < 0.05）抗糖尿病作用，提取物400 mg kg(-1)剂量组动物的血浆葡萄糖水平为248.7 +/- 5.3 mg/100 mL，而格列本脲（10 mg kg(-1)）治疗组动物的血浆葡萄糖水平为251.5 +/- 5.8 mg/100 mL。这些结果表明，给链脲佐菌素处理的大鼠服用巴戟天叶具有很强的降血糖特性。
