比较白首乌叶和辣椒果提取物在白化病大鼠体内解热作用的研究。
Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats.
机构信息
Department of Biochemistry, P.M.B 146, Federal University Lafia, Nigeria.
Department of Physiology, College of Medicine, University of Ilorin, Nigeria.
出版信息
Afr Health Sci. 2023 Mar;23(1):213-217. doi: 10.4314/ahs.v23i1.23.
BACKGROUND
leaves and fruits of are used locally in the management of fever in Nigeria. No scientific credence has been lent to this claim.
OBJECTIVE
To investigate the antipyretic effect and potency of aqueous extracts of leaves and fruits of in albino rats.
METHOD
Brewer's yeast was used to induce pyrexia. Thirty animals were divided into six groups. Group A was orally administered normal saline (103 mg/kg). Group B was served indomethacin (5 mg/kg), while groups C and D received aqueous extract of at 100mg/kg and 200mg/kg, 17 hours post induction of pyrexia. Groups E and F were administered extract of at the same doses. Rectal temperature of the animals was taken at 60-, 90- and 120-minutes post-treatment.
RESULTS
Both and produced significant reduction (p<0.05) in rectal temperature after 120 minutes in the rats compared with animals in the control group. Also, the antipyretic activities of the two extracts at 100mg/kg and 200mg/kg were comparable to 5mg/kg of indomethacin, with apparent dose dependence in the antipyretic activities of both extracts.
CONCLUSION
leaves and fruits of exhibit dose-dependent antipyretic activities.
背景
在尼日利亚， 的叶子和果实被局部用于治疗发热。但这一说法没有得到科学的证实。
目的
研究 的叶和果的水提物对白鼠的解热作用和效力。
方法
采用酵母法诱导发热。将 30 只动物分为 6 组。A 组口服生理盐水（103mg/kg）。B 组给予吲哚美辛（5mg/kg），C 组和 D 组在发热后 17 小时分别给予 100mg/kg 和 200mg/kg 的 水提取物。E 组和 F 组给予相同剂量的 提取物。在治疗后 60、90 和 120 分钟测量动物的直肠温度。
结果
与对照组相比， 和 在 120 分钟后均能显著降低大鼠的直肠温度（p<0.05）。此外，两种提取物在 100mg/kg 和 200mg/kg 时的解热活性与 5mg/kg 的吲哚美辛相当，两种提取物的解热活性均呈明显的剂量依赖性。
结论
的叶和果具有剂量依赖性的解热活性。
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