Larjava H, Haapasalmi K, Salo T, Wiebe C, Uitto V J
Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Oral Dis. 1996 Mar;2(1):77-86. doi: 10.1111/j.1601-0825.1996.tb00207.x.
Periodontal epithelium plays a critical role in protection, destruction and repair of human periodontium. During optimal repair, epithelium migrates and covers the wound surface to prevent infection and damage of the vulnerable underlying connective tissue. During periodontal destruction, junctional epithelium undergoes transformation to pocket epithelium that has quite different characteristics from junctional epithelium. In the course of periodontal disease the epithelial attachment to the tooth surface is lost and the epithelium proliferates and extends pseudo-rete ridges deep into the inflamed connective tissue. Both scenarios, repair and destruction, involve active epithelial migration either in the wound provisional matrix or in the inflamed connective tissue matrix, respectively. This review covers recent research data on cellular receptors, integrins, that mediate epithelial cell migration during wound healing and destruction of human periodontium.
牙周上皮在人类牙周组织的保护、破坏和修复过程中起着关键作用。在最佳修复过程中，上皮细胞迁移并覆盖伤口表面，以防止脆弱的下方结缔组织受到感染和损伤。在牙周组织破坏过程中，结合上皮会转变为袋上皮，其特性与结合上皮有很大不同。在牙周疾病过程中，上皮与牙面的附着丧失，上皮细胞增殖并将假上皮嵴深入延伸至炎症结缔组织中。修复和破坏这两种情况都分别涉及上皮细胞在伤口临时基质或炎症结缔组织基质中的活跃迁移。本综述涵盖了有关细胞受体整合素的最新研究数据，整合素在人类牙周组织伤口愈合和破坏过程中介导上皮细胞迁移。
