慢性丙型肝炎相关迟发性皮肤卟啉症的干扰素治疗无效，但丙型肝炎病毒RNA水平有短暂下降。
Ineffective interferon treatment of chronic hepatitis C-associated porphyria cutanea tarda, but with a transient decrease in HCV RNA levels.
作者信息
Furuta M, Kaito M, Gabazza E, Fujita N, Ishida S, Tamaki S, Ikeda R, Wakisawa S, Hayashi H, Watanabe S, Adachi Y
机构信息
Third Department of Internal Medicine, Mie University School of Medicine, Edobashi, Tsu, Japan.
出版信息
J Gastroenterol. 2000;35(1):60-2. doi: 10.1007/pl00009978.
Many patients with porphyria cutanea tarda (PCT) have been reported to be hepatitis C virus (HCV) carriers, suggesting that HCV infection plays a role in the pathogenesis of this type of porphyria. In this study, we report a patient with chronic hepatitis C-associated PCT. Therapy with interferon (IFN) transiently decreased HCV RNA levels, but levels of urinary porphyrins and serum transaminases and ferritin remained unchanged. Serum ferritin and urinary porphyrin levels improved after phlebotomy, but this therapy was not effective in improving serum transaminase levels. Although a physiopathological association between HCV infection and PCT has been suggested previously, IFN was not effective in this patient. The transient decrease in HCV RNA levels was a factor independent of porphyrin metabolism.
据报道，许多迟发性皮肤卟啉症（PCT）患者是丙型肝炎病毒（HCV）携带者，这表明HCV感染在这类卟啉症的发病机制中起作用。在本研究中，我们报告了1例慢性丙型肝炎相关的PCT患者。用干扰素（IFN）治疗可使HCV RNA水平短暂下降，但尿卟啉、血清转氨酶和铁蛋白水平保持不变。放血治疗后血清铁蛋白和尿卟啉水平有所改善，但该疗法对改善血清转氨酶水平无效。尽管先前已提示HCV感染与PCT之间存在生理病理联系，但IFN对该患者无效。HCV RNA水平的短暂下降是一个与卟啉代谢无关的因素。
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