Mingioli E S, Strober W, Tourtellotte W W, Whitaker J N, McFarlin D E
Neurology. 1978 Oct;28(10):991-5. doi: 10.1212/wnl.28.10.991.
A radioimmunoassay (RIA) for quantitating IgG, IgA and IgM in unconcentrated CSF has been developed. The amounts and percentages of these immunoglobulins in CSF from 31 normal individuals were determined. Using these values as normal, CSF from patients with syphilis, encephalitis, subacute sclerosing panencephalitis (SSPE), and multiple sclerosis (MS) was studied. Abnormalities were detected, indicating the potential relevance of more extensive study of the CSF immunoglobulins. CSF from patients with myotonic dystrophy and myasthenia gravis was normal. RIA was compared with rocket electroimmunodiffusion (EID) for the quantitation of IgG. Although RIA consistently gave lower absolute values, both assays reliably detect elevated IgG in CSF. However, an advantage of RIA is its capacity to quantitate IgA and IgM.
已开发出一种用于定量未浓缩脑脊液中IgG、IgA和IgM的放射免疫测定法（RIA）。测定了31名正常个体脑脊液中这些免疫球蛋白的含量和百分比。以这些值作为正常标准，对梅毒、脑炎、亚急性硬化性全脑炎（SSPE）和多发性硬化症（MS）患者的脑脊液进行了研究。检测到异常情况，表明对脑脊液免疫球蛋白进行更广泛研究具有潜在意义。强直性肌营养不良和重症肌无力患者的脑脊液正常。将RIA与火箭免疫电泳（EID）用于定量IgG进行了比较。尽管RIA始终给出较低的绝对值，但两种测定法都能可靠地检测出脑脊液中升高的IgG。然而，RIA的一个优点是其能够定量IgA和IgM。
