Livramento J A, Machado L R, Da Luz B R, Spina-Franca A
Arq Neuropsiquiatr. 1985 Jun;43(2):147-53. doi: 10.1590/s0004-282x1985000200004.
Immunoglobulins IgG, IgA and IgM were studied in serum and cerebrospinal fluid (CSF) samples from 36 newborn infants in the second day of life. According to parameters previously established in the same laboratory for normal newborn infants, serum proteins were normal in all samples and CSF composition was normal as to blood pigments, cells, total proteins and protein fractions in all samples. Immunoglobulins concentrations were determined by two methods: radial immunodiffusion (RID) and nephelometry. Concentrations found (mean +/- standard deviation) were as follows (mg/dl). Serum: through the RID method IgG 1346 +/- 299.1, IgM 10.4 +/- 2.26, IgA 1.1 +/- 1.06; through nephelometry IgG 1372 +/- 319.7, IgM 10.6 +/- 4.10, IgA 1.5 +/- 0.31. Cerebrospinal fluid: IgA and IgM were not detected by the methods employed; IgG was detected by both methods, and values were 11.1 +/- 2.52 by RID and 9.6 +/- 7.04 by nephelometry. IgG relations and IgG index were also evaluated; values of the IgG index (0.5 +/- 0.14) are emphasized. Considerations are made in order to point out data obtained as to characterize normal values for immunoglobulins in the cerebrospinal fluid of normal newborn infants.
对36例出生第二天的新生儿血清和脑脊液（CSF）样本中的免疫球蛋白IgG、IgA和IgM进行了研究。根据同一实验室先前为正常新生儿确定的参数，所有样本中的血清蛋白均正常，所有样本中的脑脊液成分在血色素、细胞、总蛋白和蛋白组分方面均正常。免疫球蛋白浓度通过两种方法测定：放射免疫扩散法（RID）和散射比浊法。测得的浓度（平均值±标准差）如下（mg/dl）。血清：通过RID法，IgG为1346±299.1，IgM为10.4±2.26，IgA为1.1±1.06；通过散射比浊法，IgG为1372±319.7，IgM为10.6±4.10，IgA为1.5±0.31。脑脊液：采用的方法未检测到IgA和IgM；两种方法均检测到IgG，RID法测得的值为11.1±2.52，散射比浊法测得的值为9.6±7.04。还评估了IgG关系和IgG指数；强调了IgG指数的值（0.5±0.14）。进行了相关考量，以指出所获得的数据对于确定正常新生儿脑脊液中免疫球蛋白正常值的特征。
