伴有广泛噬红细胞现象及20号染色体长臂1区1带缺失（del(20)(q11)）的微分化急性髓系白血病（AML-M0）

Minimally differentiated acute myeloid leukemia (AML-M0) with extensive erythrophagocytosis and del(20)(q11) chromosome abnormality.

作者信息

Mori H, Tawara M, Yoshida Y, Kuriyama K, Sugahara K, Kamihira S, Tomonaga M

机构信息

Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan.

出版信息

Leuk Res. 2000 Jan;24(1):87-90. doi: 10.1016/s0145-2126(99)00145-9.

DOI:10.1016/s0145-2126(99)00145-9

PMID:10634652

Abstract

We describe an 84-year-old woman who presented severe pancytopenia and 36.6% of blasts accompanied with erythrophagocytosis in the bone marrow. According to cytochemical and immunological findings, a diagnosis of minimally differentiated acute myeloid leukemia (AML-M0) was established. Cytogenetic analysis revealed del(20)(q11) which were previously reported for one case each of ALL and MDS associated with cytophagocytosis by blasts, leading us to speculate a disease entity. Interestingly, a high expression of mRNA of TNF-alpha was detected by RT-PCR on the bone marrow mononuclear cells.

摘要

我们描述了一位84岁的女性，她出现严重全血细胞减少，骨髓中原始细胞占36.6%，伴有红细胞吞噬现象。根据细胞化学和免疫学检查结果，确诊为微分化急性髓系白血病（AML-M0）。细胞遗传学分析显示del(20)(q11)，此前曾有1例急性淋巴细胞白血病（ALL）和1例骨髓增生异常综合征（MDS）伴有原始细胞吞噬现象的病例报告过此情况，这使我们推测存在一种疾病实体。有趣的是，通过逆转录聚合酶链反应（RT-PCR）检测发现骨髓单个核细胞中肿瘤坏死因子-α（TNF-α）的mRNA表达水平较高。