蜕膜Valpha14自然杀伤T细胞在流产中的作用。
Involvement of decidual Valpha14 NKT cells in abortion.
作者信息
Ito K, Karasawa M, Kawano T, Akasaka T, Koseki H, Akutsu Y, Kondo E, Sekiya S, Sekikawa K, Harada M, Yamashita M, Nakayama T, Taniguchi M
机构信息
CREST (Core Research for Evolutional Science and Technology) Project and Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Japan.
出版信息
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):740-4. doi: 10.1073/pnas.97.2.740.
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Valpha14 NKT cells expressing an invariant antigen receptor encoded by Valpha14/Jalpha281 and Vbeta7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with alpha-galactosylceramide (alpha-GalCer), a specific ligand for Valpha14 NKT cells. The alpha-GalCer-mediated abortion was not observed in Valpha14 NKT-, IFN-gamma-, tumor necrosis factor alpha-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated Valpha14 NKT cells whose perforin-dependent killing and production of IFN-gamma and tumor necrosis factor alpha were essential. The possible role of the decidual Valpha14 NKT cells in the pathogenesis of abortion is discussed.
调节流产的免疫机制在很大程度上尚不清楚。在此，我们发现了一类独特的淋巴细胞亚群，即表达由Valpha14/Jalpha281和Vbeta7基因片段编码的恒定抗原受体的Valpha14 NKT细胞，它们在孕期蜕膜中积聚，并在用α-半乳糖神经酰胺（α-GalCer，Valpha14 NKT细胞的特异性配体）刺激后引发流产。在Valpha14 NKT细胞、干扰素-γ、肿瘤坏死因子α或穿孔素基因敲除小鼠中未观察到α-GalCer介导的流产，这似乎是由于活化的Valpha14 NKT细胞介导的胚胎滋养层细胞变性所致，而这些细胞依赖穿孔素的杀伤作用以及干扰素-γ和肿瘤坏死因子α的产生至关重要。本文讨论了蜕膜Valpha14 NKT细胞在流产发病机制中的可能作用。
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