Max在早期胚胎生长和发育中的重要作用。
Essential role for Max in early embryonic growth and development.
作者信息
Shen-Li H, O'Hagan R C, Hou H, Horner J W, Lee H W, DePinho R A
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461 USA.
出版信息
Genes Dev. 2000 Jan 1;14(1):17-22.
Abstract
Loss of Max function in the mouse resulted in generalized developmental arrest of both embryonic and extraembryonic tissues at early postimplantation (approximately E5.5-6.5), coincident with loss or dilution of maternal Max stores in the expanding embryo in vivo and in blastocyst outgrowths in vitro. Developmentally arrested embryos were reduced in size and exhibited widespread cytological degeneration and feeble BrdU incorporation. Max and, by extension, the Myc superfamily, serve essential roles in early mammalian development and a maternal reservoir of Max exists in sufficient amount to sustain Myc superfamily function through preimplantation stages of development.
摘要
小鼠中Max功能的丧失导致植入后早期（约E5.5 - 6.5）胚胎和胚外组织普遍发育停滞，这与体内正在发育的胚胎以及体外囊胚外植体中母体Max储备的丧失或稀释同时发生。发育停滞的胚胎体积减小，表现出广泛的细胞退化和微弱的BrdU掺入。Max以及由此延伸的Myc超家族在早期哺乳动物发育中发挥着重要作用，并且母体Max储备量足以在发育的植入前阶段维持Myc超家族的功能。
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本文引用的文献
1
Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network.两条MAD尾巴：Mad1和Mxi1近期的基因敲除研究对MYC/MAX/MAD网络的启示
Biochim Biophys Acta. 1999 May 31;1423(3):M37-47. doi: 10.1016/s0304-419x(99)00012-8.
2
c-Myc target genes involved in cell growth, apoptosis, and metabolism.参与细胞生长、凋亡和代谢的c-Myc靶基因。
Mol Cell Biol. 1999 Jan;19(1):1-11. doi: 10.1128/MCB.19.1.1.
3
Repression by the Mad(Mxi1)-Sin3 complex.由Mad（Mxi1）-Sin3复合物介导的抑制作用。
Bioessays. 1998 Oct;20(10):808-18. doi: 10.1002/(SICI)1521-1878(199810)20:10<808::AID-BIES6>3.0.CO;2-U.
4
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.Mxi1在衰老器官系统中的作用以及对正常和肿瘤生长的调节。
Nature. 1998 Jun 4;393(6684):483-7. doi: 10.1038/31008.
5
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights.Myc在生长和转化中的分子作用：近期发现带来新见解。
FASEB J. 1998 Jun;12(9):633-51.
6
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7
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