对人类干扰素产生关闭过程中信使核糖核酸竞争的评估。
An evaluation of messenger RNA competition in the shutoff of human interferon production.
作者信息
Sehgal P B, Tamm I
出版信息
Proc Natl Acad Sci U S A. 1976 May;73(5):1621-5. doi: 10.1073/pnas.73.5.1621.
Abstract
The process that shuts off poly(I)-poly(C)-induced interferon production in a strain of diploid human fibroblasts (FS-4)-involves the synthesis of new RNA, presumably nuclear heterogeneous RNA. When cultures in the shutoff phase of interferon production are treated with actinomycin D (5 mug/ml) or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB 40 muM), the rate of interferon production continues to decline for a further 3-4 hr, but then tends to level off. The treated cultures maintain interferon production at a reduced level for at least 10 hr. The residual rate of interferon production is higher in cultures which received actinomycin D or DRB early in the shutoff phase as compared to the rate in cultures treated late.
摘要
在一株二倍体人成纤维细胞（FS - 4）中，关闭聚肌苷酸 - 聚胞苷酸诱导的干扰素产生的过程涉及新RNA的合成，推测为核不均一RNA。当处于干扰素产生关闭阶段的培养物用放线菌素D（5微克/毫升）或5,6 - 二氯 - 1 - β - D - 呋喃核糖基苯并咪唑（DRB 40微摩尔）处理时，干扰素产生速率在接下来的3 - 4小时内继续下降，但随后趋于平稳。经处理的培养物在至少10小时内维持较低水平的干扰素产生。与在关闭阶段后期处理的培养物相比，在关闭阶段早期接受放线菌素D或DRB处理的培养物中干扰素产生的残留速率更高。
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本文引用的文献
1
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Virology. 1963 Nov;21:383-9. doi: 10.1016/0042-6822(63)90199-5.
2
Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
3
Glycosides of chlorobenzimidazoles as inhibitors of poliovirus multiplication.氯苯并咪唑糖苷作为脊髓灰质炎病毒增殖抑制剂
Virology. 1957 Dec;4(3):483-98. doi: 10.1016/0042-6822(57)90081-8.
4
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
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5
Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.快速标记的海拉细胞核RNA。I. 通过区带沉降法鉴定与核糖体前体RNA分离的异质组分。
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10
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J Mol Biol. 1973 Oct 5;79(4):681-96. doi: 10.1016/0022-2836(73)90071-5.
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