Christiansen L A, Stadil F, Rehfeld J F, Tönnesen K
Scand J Gastroenterol Suppl. 1976;37:35-7.
To elucidate the role of the liver in gastrin metabolism three liver perfusions and two control experiments were performed; 2,5, 5 and 250 microgram of porcine nonsulphated gastrin-17 were injected into a perfusate of pig blood circulated through an isolated perfused liver. A significant decrease of gastrin concentration was observed during liver perfusions, concentration being halved in 35 minutes with all doses. It is suggested that this decrease is due to hepatic degradation and that the liver may play an important role in metabolism of gastrin-17.
为阐明肝脏在胃泌素代谢中的作用，进行了三次肝脏灌注和两次对照实验；将2微克、5微克、5微克和250微克的猪非硫酸化胃泌素-17注入通过离体灌注肝脏循环的猪血灌注液中。在肝脏灌注期间观察到胃泌素浓度显著降低，所有剂量下浓度在35分钟内减半。提示这种降低是由于肝脏降解所致，并且肝脏可能在胃泌素-17的代谢中起重要作用。
