Sacks H, Grant B J, Vinik A I
S Afr Med J. 1978 Feb 18;53(7):249-51.
Synthetic human heptadecapeptide gastrin-1 (SHG-17-1) and rat insulin were perfused cyclically through the isolated rat liver in a plasma-free medium. Synthetic human gastrin did not disappear from the medium at either physiological or supraphysiological levels, whereas rat insulin was cleared rapidly. Chromatography of perfusion samples showed that the SHG-17-U was neither lysed to smaller peptides nor changed to the larger molecular weight species. The isolated rat liver apparently plays no role in the metabolism of synthetic human heptadecapeptide gastrin-I.
合成人十七肽胃泌素-1（SHG-17-1）和大鼠胰岛素在无血浆培养基中循环灌注通过离体大鼠肝脏。合成人胃泌素在生理水平或超生理水平下均未从培养基中消失，而大鼠胰岛素则迅速被清除。灌注样品的色谱分析表明，SHG-17-U既未裂解为较小的肽，也未转变为较大分子量的物质。离体大鼠肝脏显然在合成人十七肽胃泌素-I的代谢中不起作用。
