Chaturvedi V, Handa R, Rao D N, Wali J P
Department of Medicine, All India Institute of Medical Sciences, New Delhi.
Indian J Med Res. 1999 May;109:170-4.
Serum and synovial fluid (SF) levels of malondialdehyde (MDA), a marker of free radical induced lipid peroxidation, were estimated in patients of rheumatoid arthritis (RA) and compared with healthy controls and patients of osteoarthritis (OA). While serum MDA levels were similar in healthy controls (0.24 +/- 0.10 nmol/ml) and OA (0.28 +/- 0.11 nmol/ml), the serum levels in RA (0.47 +/- 0.19 nmol/ml) were significantly higher as compared to both healthy controls and OA patients; and correlated with synovial fluid (SF) MDA levels. No difference was observed in SF-MDA levels in RA (0.17 +/- 0.07 nmol/ml) and OA (0.16 +/- 0.09). MDA levels did not correlate with markers of disease activity in RA like joint counts, duration of morning stiffness, erythrocyte sedimentation rate etc. Increased serum MDA levels in RA suggest the role of free radicals in the pathogenesis of this inflammatory arthropathy and support the need for further studies assessing the therapeutic role of free radical scavengers in RA.
对类风湿关节炎（RA）患者的血清和滑液（SF）中丙二醛（MDA）水平进行了评估，丙二醛是自由基诱导脂质过氧化的标志物，并与健康对照者和骨关节炎（OA）患者进行了比较。健康对照者（0.24±0.10 nmol/ml）和OA患者（0.28±0.11 nmol/ml）的血清MDA水平相似，但RA患者的血清水平（0.47±0.19 nmol/ml）与健康对照者和OA患者相比均显著更高，且与滑液（SF）MDA水平相关。RA患者（0.17±0.07 nmol/ml）和OA患者（0.16±0.09）的SF-MDA水平未观察到差异。MDA水平与RA疾病活动标志物如关节计数、晨僵持续时间、红细胞沉降率等无关。RA患者血清MDA水平升高表明自由基在这种炎性关节病发病机制中的作用，并支持进一步研究评估自由基清除剂在RA中的治疗作用的必要性。
