• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Cryptococcosis in AIDS.艾滋病中的隐球菌病
Postgrad Med J. 2000 Feb;76(892):85-8. doi: 10.1136/pmj.76.892.85.
2
Cryptococcal meningitis due to Cryptococcus neoformans genotype AFLP1/VNI in Iran: a review of the literature.伊朗新型隐球菌AFLP1/VNI基因型所致隐球菌性脑膜炎：文献综述
Mycoses. 2015 Dec;58(12):689-93. doi: 10.1111/myc.12415. Epub 2015 Oct 7.
3
Cryptococcal meningitis in AIDS.艾滋病相关性隐球菌性脑膜炎
Indian J Med Sci. 2002 Dec;56(12):593-7.
4
Cryptoccocal meningitis in Yaoundé (Cameroon) HIV infected patients: Diagnosis, frequency and Cryptococcus neoformans isolates susceptibility study to fluconazole.喀麦隆雅温得地区感染艾滋病毒患者的隐球菌性脑膜炎：诊断、发病率及新型隐球菌分离株对氟康唑的药敏研究
J Mycol Med. 2015 Mar;25(1):11-6. doi: 10.1016/j.mycmed.2014.10.016. Epub 2014 Nov 21.
5
Antifungal susceptibilities of Cryptococcus neoformans cerebrospinal fluid isolates and clinical outcomes of cryptococcal meningitis in HIV-infected patients with/without fluconazole prophylaxis.新型隐球菌脑脊液分离株的抗真菌药敏性及接受/未接受氟康唑预防治疗的HIV感染患者隐球菌性脑膜炎的临床结局
J Med Assoc Thai. 2006 Jun;89(6):795-802.
6
Cryptococcus neoformans and C. gattii isolates from both HIV-infected and uninfected patients: antifungal susceptibility and outcome of cryptococcal disease.来自HIV感染和未感染患者的新型隐球菌和格特隐球菌分离株：抗真菌药敏性及隐球菌病的转归
Rev Inst Med Trop Sao Paulo. 2017;59:e49. doi: 10.1590/S1678-9946201759049. Epub 2017 Aug 3.
7
Cryptococcal meningitis in Lilongwe and Blantyre, Malawi.马拉维利隆圭和布兰太尔的隐球菌性脑膜炎
J Infect. 1994 Jan;28(1):59-64. doi: 10.1016/s0163-4453(94)94161-0.
8
In vitro antifungal activities of amphotericin B, 5-fluorocytosine, fluconazole and itraconazole against Cryptococcus neoformans isolated from cerebrospinal fluid and blood from patients in Serbia.在体外对从塞尔维亚患者脑脊液和血液中分离的新型隐球菌的两性霉素 B、5-氟胞嘧啶、氟康唑和伊曲康唑的抗真菌活性。
J Mycol Med. 2012 Sep;22(3):243-8. doi: 10.1016/j.mycmed.2012.06.002. Epub 2012 Aug 10.
9
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial.HIV 相关隐球菌性脑膜炎的联合抗真菌治疗：一项随机试验。
Lancet. 2004 May 29;363(9423):1764-7. doi: 10.1016/S0140-6736(04)16301-0.
10
Response to therapy in patients with cryptococcosis and AIDS: Association with in vitro susceptibility to fluconazole.隐球菌病合并艾滋病患者的治疗反应：与氟康唑体外敏感性的关联。
Rev Iberoam Micol. 2015 Oct-Dec;32(4):214-20. doi: 10.1016/j.riam.2014.07.006. Epub 2014 Nov 28.

引用本文的文献

1
Comparison of Antigen Detection and Nested PCR in CSF Samples of HIV Positive and Negative Patients with Suspected Cryptococcal Meningitis in a Tertiary Care Hospital.三级护理医院中疑似新型隐球菌脑膜炎的HIV阳性和阴性患者脑脊液样本中抗原检测与巢式PCR的比较
J Clin Diagn Res. 2016 Apr;10(4):DC12-5. doi: 10.7860/JCDR/2016/18322.7619. Epub 2016 Apr 1.
2
Pulmonary cryptococcosis presenting as acute severe respiratory distress in a newly diagnosed HIV patient in Tanzania: a case report.坦桑尼亚一名新诊断的艾滋病毒患者中表现为急性严重呼吸窘迫的肺隐球菌病：病例报告
Clin Case Rep. 2015 Sep;3(9):749-52. doi: 10.1002/ccr3.337. Epub 2015 Aug 11.
3
Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.新型隐球菌超丝状菌株在隐球菌性脑膜脑炎小鼠模型中具有高毒力。
PLoS One. 2014 Aug 5;9(8):e104432. doi: 10.1371/journal.pone.0104432. eCollection 2014.
4
In vitro anti-Candida activity of certain new 3-(1H-imidazol-1-yl)propan-1-one oxime esters.某些新型 3-(1H-咪唑-1-基)丙-1-酮肟酯的体外抗假丝酵母菌活性。
Molecules. 2013 Sep 30;18(10):12208-21. doi: 10.3390/molecules181012208.
5
Cryptococcal meningoencephalitis in human immunodeficiency virus/acquired immunodeficiency syndrome in douala, cameroon: a cross sectional study.喀麦隆杜阿拉人类免疫缺陷病毒/获得性免疫缺陷综合征患者的隐球菌性脑膜脑炎：一项横断面研究
N Am J Med Sci. 2013 Aug;5(8):486-91. doi: 10.4103/1947-2714.117318.
6
Molecular epidemiology reveals genetic diversity amongst isolates of the Cryptococcus neoformans/C. gattii species complex in Thailand.分子流行病学揭示了泰国新型隐球菌/格特隐球菌种复合体分离株的遗传多样性。
PLoS Negl Trop Dis. 2013 Jul 4;7(7):e2297. doi: 10.1371/journal.pntd.0002297. Print 2013.
7
Allergen1 regulates polysaccharide structure in Cryptococcus neoformans.过敏原 1 调控新型隐球菌多糖结构。
Mol Microbiol. 2013 May;88(4):713-27. doi: 10.1111/mmi.12216. Epub 2013 Apr 9.
8
An update on Cryptococcus among HIV-infected patients.HIV感染患者中隐球菌病的最新情况。
Int J STD AIDS. 2010 Oct;21(10):679-84. doi: 10.1258/ijsa.2010.010182.
9
International collaboration between US and Thailand on a clinical trial of treatment for HIV-associated cryptococcal meningitis.美国和泰国在一项治疗 HIV 相关隐球菌性脑膜炎的临床试验中的国际合作。
Contemp Clin Trials. 2010 Jan;31(1):34-43. doi: 10.1016/j.cct.2009.11.002. Epub 2009 Nov 6.
10
Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa.在南非接受抗逆转录病毒治疗项目的患者中进行隐球菌抗原血症筛查。
Clin Infect Dis. 2009 Apr 1;48(7):856-62. doi: 10.1086/597262.

本文引用的文献

1
Prevalence of serotype D in Cryptococcus neoformans isolates from HIV positive and HIV negative patients in Italy.意大利HIV阳性和HIV阴性患者新生隐球菌分离株中D血清型的流行情况。
Mycoses. 1997 Nov;40(7-8):297-302. doi: 10.1111/j.1439-0507.1997.tb00235.x.
2
Isolation of specific DNA probes for detection of Cryptococcus neoformans.用于检测新型隐球菌的特异性DNA探针的分离
Mycoses. 1997 Dec;40(9-10):385-9. doi: 10.1111/j.1439-0507.1997.tb00256.x.
3
Identification by polymerase chain reaction fingerprinting of Cryptococcus neoformans serotype AD.通过聚合酶链反应指纹图谱鉴定新型隐球菌AD血清型。
J Med Vet Mycol. 1997 Sep-Oct;35(5):355-60.
4
Serotyping of Cryptococcus neoformans strains isolated from clinical specimens in Thailand and their susceptibility to various antifungal agents.泰国临床标本分离的新型隐球菌菌株的血清型及其对各种抗真菌药物的敏感性。
Eur J Epidemiol. 1997 Apr;13(3):335-40. doi: 10.1023/a:1007376917836.
5
Visual loss in immunocompetent patients with Cryptococcus neoformans var. gattii meningitis.免疫功能正常的新型隐球菌格特变种脑膜炎患者的视力丧失
Trans R Soc Trop Med Hyg. 1997 Jan-Feb;91(1):44-9. doi: 10.1016/s0035-9203(97)90391-6.
6
Assessment of a PCR technique for the detection and identification of Cryptococcus neoformans.用于检测和鉴定新型隐球菌的聚合酶链反应（PCR）技术评估
J Med Vet Mycol. 1996 Jul-Aug;34(4):251-8. doi: 10.1080/02681219680000431.
7
In vitro determination of optimal antifungal combinations against Cryptococcus neoformans and Candida albicans.针对新型隐球菌和白色念珠菌的体外最佳抗真菌组合测定
Antimicrob Agents Chemother. 1995 Nov;39(11):2459-65. doi: 10.1128/AAC.39.11.2459.
8
Two-site comparison of broth microdilution and semisolid agar dilution methods for susceptibility testing of Cryptococcus neoformans in three media.在三种培养基中对新型隐球菌进行药敏试验时肉汤微量稀释法和半固体琼脂稀释法的双位点比较
J Clin Microbiol. 1993 May;31(5):1370-2. doi: 10.1128/jcm.31.5.1370-1372.1993.
9
Hybridization probes for conventional DNA fingerprinting used as single primers in the polymerase chain reaction to distinguish strains of Cryptococcus neoformans.用于传统DNA指纹识别的杂交探针在聚合酶链反应中用作单引物，以区分新型隐球菌菌株。
J Clin Microbiol. 1993 Sep;31(9):2274-80. doi: 10.1128/jcm.31.9.2274-2280.1993.
10
Comparative study of broth macrodilution and microdilution techniques for in vitro antifungal susceptibility testing of yeasts by using the National Committee for Clinical Laboratory Standards' proposed standard.采用美国国家临床实验室标准委员会提议的标准，对肉汤稀释法的常量稀释和微量稀释技术用于酵母体外抗真菌药敏试验进行比较研究。
J Clin Microbiol. 1994 Oct;32(10):2494-500. doi: 10.1128/jcm.32.10.2494-2500.1994.

艾滋病中的隐球菌病

Cryptococcosis in AIDS.

作者信息

Imwidthaya P, Poungvarin N

机构信息

Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

出版信息

Postgrad Med J. 2000 Feb;76(892):85-8. doi: 10.1136/pmj.76.892.85.

DOI:10.1136/pmj.76.892.85
PMID:10644384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1741486/
Abstract

A total of 87 patients (17 female, 70 male) were admitted to SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND, from JANUARY 1996 TO DECEMBER 1997, with a diagnosis of cryptococcal meningitis and underlying AIDS. The age range was 14: 70 years, mean 32.1. Six females (35%) and thirty-one males (44%) died, while the others were discharged home after clinical improvement. The mean duration of admission of those who died was 14.5 days, which was shorter than that of the patients who survived (25.7 days). Cerebral cryptococcosis was diagnosed using culture (100%), India ink preparation (91%), latex agglutination test (100%), and polymerase chain reaction (86%). Polymerase chain reaction fingerprinting of Cryptococcus neoformans revealed 99% serotype A and 1% serotype B. The mean minimum inhibitory concentrations of amphotericin B, flucytosine, fluconazole and itraconazole against 87 isolates of C neoformans were 0.55 microg/ml (0.25-1, SD = 0.22), 9.5 microg/ml (2-20, SD = 4.91), 6.9 microg/ml (1-16, SD = 4.42) and 0.36 microg/ml (0.125-1.0, SD = 0.23), respectively. These findings showed that the cryptococcal infections were sensitive to these antifungal agents.

摘要

1996年1月至1997年12月期间，共有87例患者（17例女性，70例男性）入住泰国曼谷玛希隆大学诗里拉吉医院，诊断为隐球菌性脑膜炎并伴有潜在的艾滋病。年龄范围为14至70岁，平均32.1岁。6名女性（35%）和31名男性（44%）死亡，其他患者在临床症状改善后出院回家。死亡患者的平均住院时间为14.5天，短于存活患者（25.7天）。采用培养法（100%）、印度墨汁涂片法（91%）、乳胶凝集试验（100%）和聚合酶链反应（86%）诊断脑隐球菌病。新型隐球菌的聚合酶链反应指纹图谱显示99%为A型血清型，1%为B型血清型。两性霉素B、氟胞嘧啶、氟康唑和伊曲康唑对87株新型隐球菌的平均最低抑菌浓度分别为0.55微克/毫升（0.25 - 1，标准差 = 0.22）、9.5微克/毫升（2 - 20，标准差 = 4.91）、6.9微克/毫升（1 - 16，标准差 = 4.42）和0.36微克/毫升（0.125 - 1.0，标准差 = 0.23）。这些结果表明隐球菌感染对这些抗真菌药物敏感。