Forbes P D, Urbach F
Environ Qual Saf Suppl. 1975;4:212-22.
These studies were designed to determine whether fluorescent whitening agents (FWAs) could: (I) produce an augmented acute response of skin to a single ultraviolet light exposure (i.e., phototoxicity), or (II) increase the number or hasten the appearance of skin tumors after several ultraviolet light exposures (i.e., chemically enhanced photocarcinogenesis). Five substituted stilbene FWAs were screened for phototoxicity. The results of pretreatment with these agents were compared with pretreatment by a known photoxic agent, 8-methoxypsoralen (8-MOP) or the vehicle (methanol) using the skin of hairless mice, miniature pigs, and man. None of the FWAs was phototoxic. Photocarcinogenesis testing involved pretreating hairless mouse skin with FWAs, 8-MOP, or methanol only before each daily exposure to simulated solar ultraviolet light. In terms of tumor yield and tumor development time, photocarcinogenesis was enhanced by 8-MOP, but not by FWAs.
这些研究旨在确定荧光增白剂（FWAs）是否能够：（I）使皮肤对单次紫外线照射产生增强的急性反应（即光毒性），或（II）在多次紫外线照射后增加皮肤肿瘤的数量或加速其出现（即化学增强光致癌作用）。对五种取代二苯乙烯类荧光增白剂进行了光毒性筛选。使用无毛小鼠、小型猪和人的皮肤，将用这些试剂预处理的结果与用已知光毒性试剂8-甲氧基补骨脂素（8-MOP）或赋形剂（甲醇）预处理的结果进行比较。没有一种荧光增白剂具有光毒性。光致癌作用测试包括仅在每天暴露于模拟太阳紫外线之前，用荧光增白剂、8-MOP或甲醇对无毛小鼠皮肤进行预处理。就肿瘤产量和肿瘤发展时间而言，8-MOP可增强光致癌作用，但荧光增白剂则不能。
