Lorke D, Machemer L
Environ Qual Saf Suppl. 1975;4:239-46.
Mytagecity studies were carried out with fluorescent whitening agents (FWAs) using the dominant lethal test on male mice. Own tests with five FWAs, and those of KEPLINGER, et al. (Toxicol. Appl. Pharmacol.27: 494-506, 1974), with four FWAs, are described. In our tests, acute oral administration of five FWAs at a dose of 5000 mg/kg body weight gave no evidence of a mutagenic effect during 8 weeks' mating. The FWAs used were three bis(triazinylamino)stilbenedisulfonic acid derivatives and a 1,3-diphenyl-2-pyrazoline derivative. The results of the tests carried out by KEPLINGER, et al. showed that intraperitoneal injection of the four FWAs produced no mutagenic effect during six weeks' mating; the whiteners used were a triazolylstilbenemonosulfonic acid derivative (50 mg/kg), two bis(triazinylamino)stilbenedisulfonic acid derivatives (50 mg/kg) and a bis(sulfostyryl)biphenyl derivative (10 mg/kg).
利用雄性小鼠显性致死试验，对荧光增白剂（FWA）开展了“我的城市”研究。描述了我们用5种FWA进行的试验以及KEPLINGER等人（《毒理学与应用药理学》27: 494 - 506, 1974）用4种FWA进行的试验。在我们的试验中，以5000毫克/千克体重的剂量对5种FWA进行急性口服给药，在8周的交配期内未发现诱变作用迹象。所用的FWA为3种双（三嗪基氨基）二苯乙烯二磺酸衍生物和1种1,3 - 二苯基 - 2 - 吡唑啉衍生物。KEPLINGER等人进行的试验结果表明，在6周的交配期内，对4种FWA进行腹腔注射未产生诱变作用；所用的增白剂为1种三唑基二苯乙烯单磺酸衍生物（50毫克/千克）、2种双（三嗪基氨基）二苯乙烯二磺酸衍生物（50毫克/千克）和1种双（磺基苯乙烯基）联苯衍生物（10毫克/千克）。
