Christiansen S, Stypmann J, Tjan T D, Wichter T, Van Aken H, Scheld H H, Hammel D
Klinik und Poliklinik für Thorax-, Herz- und Gefässchirurgie, Westfälische Wilhelms-Universität Münster, Germany.
Eur J Cardiothorac Surg. 1999 Dec;16(6):647-52. doi: 10.1016/s1010-7940(99)00333-4.
We performed a case-control-study to compare perioperative and mid-term results of minimally invasive with conventional aortic valve replacement.
Between 8/96 and 7/97, 113 patients underwent isolated aortic valve replacement (minimally invasive: 29, conventional: 84) in our Department. Diagnosis, ejection fraction, pressure gradient/regurgitation fraction, age, gender and body-mass-index were used as matching criteria for the case-control-study. For qualitative data correspondence was requested, for quantitative data deviations up to 10% were accepted. With these criteria 25 patients of the minimally invasive group were matched to 25 patients of conventional group. All patients were reexplored 1 year after aortic valve replacement. Statistical analysis was done by the Fisher's exact test for qualitative data and the Mann-Whitney test for quantitative data.
We implanted 15 (20) bioprosthesis' and 10 (five) mechanical prosthesis' in the minimally invasive, respectively, conventional group. There were no statistically significant differences between both groups with respect to the perioperative course, only duration of surgery (mean 201.6 vs. 143.9 min, P < 0.01) and extracorporeal circulation (mean 116.1 vs. 71.3 min, P < 0.01) as well as aortic-cross-clamp-time (mean 77.9 vs. 46.9 min, P < 0.01) were significantly longer in the minimally invasive group. Postoperative complications occurred in one patient of the minimally invasive group (dissection of the right coronary artery) and four patients of the conventional group (third degree AV block, pneumothorax, grand mal convulsion, cardiopulmonary resuscitation). Two patients, one of each group, died during follow-up for unknown reasons. Follow-up revealed no significant differences with respect to clinical and echocardiographic data, but the shorter skin incision was cosmetically more accepted by patients of the minimally invasive group. Minor paravalvular leaks occurred in four patients of the minimally invasive and three patients of the conventional group as diagnosed by transthoracic echocardiography.
Both surgical techniques may be performed with comparable perioperative and mid-term results, but the better cosmetic result in the minimally invasive group is paid by a longer duration of surgery.
我们进行了一项病例对照研究,以比较微创主动脉瓣置换术与传统主动脉瓣置换术的围手术期及中期结果。
1996年8月至1997年7月期间,我院113例患者接受了单纯主动脉瓣置换术(微创组:29例;传统组:84例)。诊断、射血分数、压力阶差/反流分数、年龄、性别及体重指数用作病例对照研究的匹配标准。对于定性数据要求对应,对于定量数据允许10%以内的偏差。按这些标准,微创组25例患者与传统组25例患者进行匹配。所有患者在主动脉瓣置换术后1年接受复查。定性数据采用Fisher精确检验进行统计分析,定量数据采用Mann-Whitney检验进行统计分析。
微创组和传统组分别植入了15个(20个)生物瓣和10个(5个)机械瓣。两组围手术期过程无统计学显著差异,仅手术时间(平均201.6对143.9分钟,P<0.01)、体外循环时间(平均116.1对71.3分钟,P<0.01)以及主动脉阻断时间(平均77.9对46.9分钟,P<0.01)在微创组明显更长。微创组1例患者发生术后并发症(右冠状动脉夹层),传统组4例患者发生术后并发症(三度房室传导阻滞、气胸、癫痫大发作、心肺复苏)。随访期间,每组各有1例患者不明原因死亡。随访显示临床和超声心动图数据无显著差异,但微创组较短的皮肤切口在美容方面更易被患者接受。经胸超声心动图诊断显示,微创组4例患者和传统组3例患者发生轻微瓣周漏。
两种手术技术的围手术期及中期结果相当,但微创组更好的美容效果是以更长的手术时间为代价的。