Ekenved G, Halvorsen L, Sölvell L
Scand J Haematol Suppl. 1976;28:65-77. doi: 10.1111/j.1600-0609.1976.tb00349.x.
The influence of a liquid antacid on the absorption of iron from iron tablets was studied in healthy volunteers using a serum iron technique. Tablets containing ferrous salts (carbonate, fumarate, sulphate) with different in-vitro dissolution properties were studied. Co-administration of the antacid and the iron tablets resulted in a marked reduction of the absorption of iron from all preparations studied. The lowest absorption was found when ferrous carbonate was given with the antacid. This was ascribed to the fact that ferrous carbonate is almost completely insoluble at pH-levels near neutral. This was confirmed in a series of patients with achlorhydria in which the absorption from ferrous carbonate was virtually nil. It was concluded that iron tablets and antacid preparations should not be administered at the same time and that ferrous carbonate tablets should not be used in patients with achlorhydria.
采用血清铁技术，在健康志愿者中研究了液体抗酸剂对铁片中铁吸收的影响。研究了含有不同体外溶解特性的亚铁盐（碳酸盐、富马酸盐、硫酸盐）的片剂。抗酸剂与铁片同时服用导致所研究的所有制剂中铁的吸收显著降低。当碳酸亚铁与抗酸剂一起服用时，吸收最低。这归因于碳酸亚铁在接近中性的pH值水平几乎完全不溶。这在一系列胃酸缺乏症患者中得到证实，其中碳酸亚铁的吸收几乎为零。得出的结论是，铁片和抗酸剂制剂不应同时服用，并且碳酸亚铁片不应用于胃酸缺乏症患者。
