Simon A
Centre de médecine préventive cardiovasculaire Hôpital Broussais, Paris.
Rev Prat. 1999 Dec 1;49(19):2104-9.
Several markers of preclinical atherosclerosis are currently available, such as: wall thickening and stiffening and endothelial dysfunction of large peripheral arteries detected by ultrasonography, or coronary calcification detected by ultrafast computed tomography. They reflect the integrated effects over time of multiple risk factors, traditional and emerging, and some of them (wall thickening and coronary calcification) have demonstrated a powerful predictive value as regards subsequent clinical events. Also these markers are invaluable targets for testing the effects of preventive treatments. Their detection should help selecting those asymptomatic subjects at risk for cardiovascular disease in whom prevention is justified.
目前有几种临床前动脉粥样硬化的标志物，例如：通过超声检测到的外周大动脉壁增厚、僵硬及内皮功能障碍，或通过超速计算机断层扫描检测到的冠状动脉钙化。它们反映了多种传统和新出现的危险因素随时间的综合影响，其中一些（壁增厚和冠状动脉钙化）已证明对后续临床事件具有强大的预测价值。这些标志物也是测试预防性治疗效果的重要靶点。它们的检测应有助于筛选出那些有心血管疾病风险且有必要进行预防的无症状受试者。
