Hyalodendrosides A and B, antifungal triterpenoid glycosides from a lignicolous hyphomycete, Hyalodendron species.

作者信息

Bills G, Dombrowski A, Morris S A, Hensens O, Liesch J M, Zink D L, Onishi J, Meinz M S, Rosenbach M, Thompson J R, Schwartz R E

机构信息

Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.

出版信息

J Nat Prod. 2000 Jan;63(1):90-4. doi: 10.1021/np9903898.

DOI:10.1021/np9903898

PMID:10650085

Abstract

Two antifungal triterpenoid glycosides, hyalodendrosides A and B (1 and 2), were isolated from a solid matrix fermentation of a lignicolous hyphomycete, Hyalodendron sp. Their structures were determined based upon extensive examination of spectral parameters, particularly NMR and MS data. Both compounds have beta-linked glucose moieties. Compounds 1 and 2 show weak to moderate antifungal activity against some clinically relevant fungi.

摘要