两种来自巢菜属植物种子的具有抗真菌活性的三萜皂苷。

Two antifungal active triterpenoid saponins from the seeds of Lathyrus plants.

机构信息

Department of Postgraduate and Research in Chemistry, R. D. University of Jabalpur, Jabalpur - 482001, M.P., India.

出版信息

Nat Prod Res. 2011 Oct;25(18):1687-94. doi: 10.1080/14786419.2011.561205. Epub 2011 Sep 8.

DOI:10.1080/14786419.2011.561205

Abstract

Two novel triterpenoid glycosides have been isolated from butanolic seeds extract of two varieties of Lathyrus plants, i.e. Lathyrus ratan and Lathyrus aphaca. Their structures were elucidated as 3-O-[β-D-glucuronopyranosyl-(1 → 4)-α-L-arabinopyranosyl-(1 → 2)-α-L-arabinopyranosyl]-olean-11,13(18)-dien-28-oic acid (1) and 3-O-{β-D-xylopyranosyl-(1 → 2)-β-D-glcopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-β-D-xylopyranosyl}-2,16α-dihydroxy-4-hydroxymethyl urs-12-en-28-oic acid (2) on the basis of spectral evidences, i.e. FTIR, (1)H-NMR, (13)C-NMR, ESI-MS and FAB-MS data. The isolated saponins were tested for their antifungal activity. Compound 1 showed maximum inhibition against Colletotrichum dematium (77.8%), whereas compound 2 showed maximum inhibition against Alternaria alternata (53.9%).

摘要

从两种雀麦植物（Lathyrus ratan 和 Lathyrus aphaca）的正丁醇种子提取物中分离得到两种新的三萜糖苷。它们的结构被阐明为 3-O-[β-D-吡喃葡萄糖醛酸基-(1 → 4)-α-L-阿拉伯吡喃糖基-(1 → 2)-α-L-阿拉伯吡喃糖基]-齐墩果酸 11,13(18)-二烯-28-酸（1）和 3-O-{β-D-吡喃木糖基-(1 → 2)-β-D-吡喃葡萄糖基-(1 → 4)-[β-D-吡喃葡萄糖基-(1 → 2)]-β-D-吡喃木糖基}-2,16α-二羟基-4-羟甲基熊-12-烯-28-酸（2）。基于光谱证据，即 FTIR、（1）H-NMR、（13）C-NMR、ESI-MS 和 FAB-MS 数据。对分离得到的皂苷进行了抗真菌活性测试。化合物 1 对炭疽菌（Colletotrichum dematium）的抑制作用最大（77.8%），而化合物 2 对交链孢菌（Alternaria alternata）的抑制作用最大（53.9%）。