Yuan J M, Wang X L, Xiang Y B, Gao Y T, Ross R K, Yu M C
Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033, USA.
Int J Cancer. 2000 Feb 1;85(3):364-9.
A population-based case-control study was conducted in Shanghai, China, to investigate the associations between exposures to various non-dietary variables and risk of nasopharyngeal carcinoma (NPC). A total of 935 NPC patients and 1,032 community controls were included. Active cigarette smoking was a moderate risk factor for NPC [odds ratio (OR) = 1.28, 95% confidence interval (CI) 1.02-1.61]. Results were highly consistent between men and women. It is estimated that 12% of NPC cases in Shanghai, China, can be attributable to cigarette smoking. Among lifelong nonsmokers, there was a strong and statistically significant positive association between NPC risk and exposure to substantial secondhand smoke as a child or as an adult in women. However, the associations among lifelong nonsmoking men were weaker and not statistically significant. The gender differences in risk associated with passive smoking were either statistically significant or almost so. There were excess numbers of NPC patients compared with control subjects who had a history of chronic ear and nose disease (OR = 1.96, 95% CI 1.56-2.46) and a family history of NPC (OR = 7.47, 95% CI 2.14-12.88).
在中国上海开展了一项基于人群的病例对照研究，以调查各种非饮食变量暴露与鼻咽癌（NPC）风险之间的关联。共纳入了935例NPC患者和1032名社区对照。主动吸烟是NPC的中度风险因素[比值比（OR）=1.28，95%置信区间（CI）1.02 - 1.61]。男性和女性的结果高度一致。据估计，在中国上海，12%的NPC病例可归因于吸烟。在终身不吸烟者中，女性儿童期或成年期大量接触二手烟与NPC风险之间存在强烈且具有统计学意义的正相关。然而，终身不吸烟男性中的这种关联较弱且无统计学意义。被动吸烟相关风险的性别差异具有统计学意义或几乎具有统计学意义。与有慢性耳鼻疾病史（OR = 1.96，95% CI 1.56 - 2.46）和NPC家族史（OR = 7.47，95% CI 2.14 - 12.88）的对照受试者相比，NPC患者数量过多。
