源自肥皂草的新型三萜皂苷和皂苷元。
New triterpenoid saponins and sapogenins from Saponaria officinalis.
作者信息
Koike K, Jia Z, Nikaido T
机构信息
Department of Pharmacognosy, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
出版信息
J Nat Prod. 1999 Dec;62(12):1655-9. doi: 10.1021/np990311r.
Five new triterpenoid saponins, named saponariosides I-M, were isolated from the whole plants of Saponario officinalis. Their structures were established as saponarioside I (1) 3-O-beta-D-xylopyranosyl-16 alpha-hydroxygypsogenic acid 28-O-alpha-D-galactopyranosyl-(1-->6)-beta-D- glucopyranosyl-(1-->3)[-beta-D-glucopyranoside[, saponarioside J (3) 3-O-beta-D-xylopyranosylolean-11,13(18)-diene-23,28-dioic acid 28-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->6)[- beta-D-glucopyranoside[, saponarioside K (4) 3,4-seco-16 alpha-hydroxygypsogenic acid 28-O-beta-D-glucopyranosyl- (1-->3)-beta-D-glucopyranosyl-(1-->6)[-beta-D-glucopyranoside[, saponarioside L (5) 3-O-beta-D-xylopyranosylgypsogenic acid 28-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->6)[-beta- D- glucopyranoside[, and saponarioside M (6) 3-O-beta-D-glucopyrano-sylgypsogenic acid 28-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1--6)-beta-D- glucopyranoside[ by NMR studies and chemical degradations. The aglycons of saponariosides J (3) and K (4) are new sapogenins.
从药用肥皂草的全株中分离出了5种新的三萜皂苷，命名为肥皂草皂苷I - M。通过核磁共振研究和化学降解确定了它们的结构，肥皂草皂苷I（1）为3 - O - β - D - 吡喃木糖基 - 16α - 羟基齐墩果酸28 - O - α - D - 吡喃半乳糖基 -（1→6）- β - D - 吡喃葡萄糖基 -（1→3）[-β - D - 葡萄糖苷]，肥皂草皂苷J（3）为3 - O - β - D - 吡喃木糖基齐墩果 - 11,13（18）- 二烯 - 23,28 - 二酸28 - O - β - D - 吡喃葡萄糖基 -（1→3）- β - D - 吡喃葡萄糖基 -（1→6）[-β - D - 葡萄糖苷]，肥皂草皂苷K（4）为3,4 - 裂环 - 16α - 羟基齐墩果酸28 - O - β - D - 吡喃葡萄糖基 -（1→3）- β - D - 吡喃葡萄糖基 -（1→6）[-β - D - 葡萄糖苷]，肥皂草皂苷L（5）为3 - O - β - D - 吡喃木糖基齐墩果酸28 - O - β - D - 吡喃葡萄糖基 -（1→3）- β - D - 吡喃葡萄糖基 -（1→6）[-β - D - 葡萄糖苷]，肥皂草皂苷M（6）为3 - O - β - D - 吡喃葡萄糖基齐墩果酸28 - O - β - D - 吡喃葡萄糖基 -（1→2）- β - D - 吡喃葡萄糖基 -（1→6）- β - D - 葡萄糖苷]。肥皂草皂苷J（3）和K（4）的苷元是新的皂苷元。
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