Vutova K, Mechkov G, Vachkov P, Petkov R, Georgiev P, Handjiev S, Ivanov A, Todorov T
Department of Infectious Diseases, Parasitology, Epidemiology and Tropical Medicine, Faculty of Medicine, University of Medicine, Sofia, Bulgaria.
Ann Trop Med Parasitol. 1999 Jun;93(4):357-65. doi: 10.1080/00034989958357.
Fifty-three patients with single, multiple and/or multi-organ hydatid cysts were treated with mebendazole, in varying dosages (30-70 mg/kg.day) and over varying periods (6-24 months). Treatment failure was recorded if the mebendazole had no apparent effect on cyst morphology (monitored by radiology, ultrasonography and computed tomography) or only a parasitostatic effect (characterized by mixed and transitory, hypo- and hyper-echoic changes in the lesions). Cure was indicated by a parasitocidal effect (characterized by a totally echogenic picture, increased density of the cyst contents, reduction in the size or complete disappearance of the cysts, complete detachment of the endocysts and/or calcification of the cyst wall). Treatment failure was seen in about 40% of the patients and cure in about 38%; the other 23% had an intermediate result considered as an improvement. Cure rates increased both with dosage and duration, daily dosages of 60-70, 50 and 30-40 mg/kg curing 48%, 33% and 25%, respectively. The pre-treatment condition of any cysts should be taken into consideration when determining dosage and treatment duration.
53例患有单个、多个和/或多器官包虫囊肿的患者接受了甲苯咪唑治疗，剂量（30 - 70毫克/千克·天）和疗程（6 - 24个月）各不相同。如果甲苯咪唑对囊肿形态没有明显影响（通过放射学、超声检查和计算机断层扫描监测）或只有抑菌作用（表现为病变内混合性和短暂性的低回声和高回声变化），则记录为治疗失败。杀虫作用（表现为完全呈高回声图像、囊肿内容物密度增加、囊肿大小缩小或完全消失、内囊完全分离和/或囊肿壁钙化）则表明治愈。约40%的患者治疗失败，约38%的患者治愈；另外23%的患者有被视为改善的中间结果。治愈率随剂量和疗程增加，每日剂量60 - 70毫克/千克、50毫克/千克和30 - 40毫克/千克的治愈率分别为48%、33%和25%。在确定剂量和疗程时应考虑任何囊肿的治疗前状况。
