Oliveira A N, Andrade M C, Silva M V, Moura W C, Cortez Contreiras E
Centro de Controle de Zoonoses Paulo Dacorso Filho, Rio de Janeiro, RJ, 23550-050, Brasil.
Mem Inst Oswaldo Cruz. 2000 Jan-Feb;95(1):83-8. doi: 10.1590/s0074-02762000000100013.
In order to determine the best type of rabies vaccine to use as a booster, 78 serological samples from singly vaccinated cattle were analyzed by counterimmunoelectrophoresis technique. The animals were divided into several groups, received the first vaccine dose with modified live virus vaccine (ERA strain) and were revaccinated with inactivated virus or modified live virus vaccines. Boosters were given at 2, 4, 8, 12 and 16 weeks following first vaccination. Results showed high titres in the cases of booster with inactivated vaccine. In all cases, however, detectable antibody titres declined quickly.
为了确定用作加强针的最佳狂犬病疫苗类型，采用对流免疫电泳技术对78份单次接种疫苗的牛的血清样本进行了分析。将这些动物分成几组，先用改良活病毒疫苗（ERA株）接种第一剂疫苗，然后用灭活病毒疫苗或改良活病毒疫苗进行再次接种。在首次接种疫苗后的2、4、8、12和16周给予加强针。结果显示，使用灭活疫苗作为加强针时抗体滴度较高。然而，在所有情况下，可检测到的抗体滴度下降很快。
