Ritter R C, Covasa M, Matson C A
Department of VCAPP and Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
Neuropeptides. 1999 Oct;33(5):387-99. doi: 10.1054/npep.1999.0051.
Evidence that CCK participates in the control of meal size is compelling, but the avenues by which CCK may affect daily food intake and body weight regulation are still uncertain. Although participation of brain CCK in control of food intake is acknowledged, our focus here is on participation of peripheral CCK in the control of food intake. Therefore, in this article we (1) review evidence for CCK's participation in control of meal size, (2) document involvement of CCK-A receptors located on vagal sensory neurons in control of food intake by exogenous and endogenous CCK, (3) point out apparent discrepancies in the experimental record, which auger for non-endocrine sources of CCK and non-vagal sites of CCK action, and (4) summarize recent observations, suggesting mechanisms by which CCK could participate in the control of daily food intake and body weight regulation.
胆囊收缩素（CCK）参与进餐量控制的证据确凿，但CCK影响每日食物摄入量和体重调节的途径仍不明确。尽管大脑中的CCK参与食物摄入控制已得到公认，但我们在此关注的是外周CCK在食物摄入控制中的作用。因此，在本文中，我们（1）回顾CCK参与进餐量控制的证据，（2）记录位于迷走感觉神经元上的CCK-A受体在外源性和内源性CCK控制食物摄入中的作用，（3）指出实验记录中明显的差异，这表明存在CCK的非内分泌来源和CCK作用的非迷走部位，（4）总结近期的观察结果，提出CCK可能参与每日食物摄入量和体重调节控制的机制。
