弗瑞德白血病病毒的宿主限制：前病毒的合成与整合
Host restriction of Friend leukemia virus: synthesis and integration of the provirus.
作者信息
Sveda M M, Soeiro R
出版信息
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2356-60. doi: 10.1073/pnas.73.7.2356.
Abstract
Host restriction of exogenous infection by murine leukemia viruses is controlled in vitro predominantly by the murine Fv-1 locus. The mechanism of this host restriction was investigated by comparing the early events in the replication of N-tropic versus B-tropic Friend leukemia virus in NIH 3T3 cells. These cells, which are Fv-1nn in type, are permissive for the N-tropic strain, but nonpermissive for the B-tropic strain, which replicates permissively in Balb/c cells. We have studied the synthesis, intracellular location, and molecular form of virus-specific DNA early in replication by means of molecular hybridization with a virus-specific DNA probe. Our results suggest that in the permissive infection viral DNA rapidly becomes integrated with cellular DNA. However, in the nonpermissive infection, although almost equal amounts of both positive and negative strand viral DNA are synthesized, integration of the provirus does not occur.
摘要
鼠白血病病毒对外源感染的宿主限制在体外主要由小鼠Fv-1基因座控制。通过比较N-嗜性与B-嗜性Friend白血病病毒在NIH 3T3细胞中复制的早期事件，研究了这种宿主限制的机制。这些细胞类型为Fv-1nn，对N-嗜性毒株敏感，但对B-嗜性毒株不敏感，B-嗜性毒株在Balb/c细胞中能顺利复制。我们通过用病毒特异性DNA探针进行分子杂交，研究了复制早期病毒特异性DNA的合成、细胞内定位和分子形式。我们的结果表明，在允许性感染中，病毒DNA迅速与细胞DNA整合。然而，在非允许性感染中，尽管正负链病毒DNA的合成量几乎相等，但前病毒的整合并未发生。
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