弗瑞德白血病病毒的宿主限制。病毒外膜的作用。
Host restriction of Friend leukemia virus. Role of the viral outer coat.
作者信息
Krontiris T G, Soeiro R, Fields B N
出版信息
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2549-53. doi: 10.1073/pnas.70.9.2549.
Abstract
Host restriction of oncogenesis of RNA tumor viruses in vivo is associated with several gene loci. One of these genes, the Fv-1 locus in mice, is expressed in vitro and may be studied in mouse-embryo cultures that are restrictive or permissive for replication of Friend leukemia virus. Two strains of Friend leukemia virus, N-or B-tropic, show reciprocal ability to replicate successfully in either NIH Swiss (N-type) or BALB/c (B-type) cells that differ at the Fv-1 locus. These two strains of virus and two cell lines form a system to measure host restriction in vitro. Measurement of adsorption of Friend leukemia virus to permissive or restrictive cells reveals no difference in rate or total amount of virus bound. Furthermore, studies with virions of vesicular stomatitis virus phenotypically mixed within an envelope containing Friend leukemia virus protein show no differences in penetration or replication of vesicular stomatitis virus. These results strongly suggest that host restriction of Friend leukemia virus is due to an intracellular event in the viral replication cycle.
摘要
体内RNA肿瘤病毒致癌作用的宿主限制与多个基因位点相关。其中一个基因，即小鼠中的Fv - 1位点，在体外表达，并且可以在对Friend白血病病毒复制具有限制性或允许性的小鼠胚胎培养物中进行研究。两种Friend白血病病毒株，N型或B型嗜性，在Fv - 1位点不同的NIH瑞士（N型）或BALB / c（B型）细胞中显示出相互成功复制的能力。这两种病毒株和两种细胞系形成了一个在体外测量宿主限制的系统。对Friend白血病病毒吸附到允许性或限制性细胞的测量显示，结合的病毒速率或总量没有差异。此外，对在含有Friend白血病病毒蛋白的包膜内进行表型混合的水疱性口炎病毒颗粒的研究表明，水疱性口炎病毒的穿透或复制没有差异。这些结果强烈表明，Friend白血病病毒的宿主限制是由于病毒复制周期中的细胞内事件。
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Host restriction of Friend leukemia virus. Role of the viral outer coat.弗瑞德白血病病毒的宿主限制。病毒外膜的作用。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2549-53. doi: 10.1073/pnas.70.9.2549.
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ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS. 3. DETERMINING INFLUENCE OF A NEW HELPER VIRUS ON THE HOST RANGE AND SUSCEPTIBILITY TO INTERFERENCE OF RSV.劳氏肉瘤病毒缺陷性分析。3. 一种新型辅助病毒对劳氏肉瘤病毒宿主范围及干扰敏感性的影响测定
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A genetic locus for inducibility of C-type in BALB-c cells: the effect of a nonlinked regulatory gene on detection of virus after chemical activation.BALB-c细胞中C型诱导性的一个基因位点：一个非连锁调节基因对化学激活后病毒检测的影响。
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Inherited resistance to N- and B-tropic murine leukemia viruses in vitro: evidence that congenic mouse strains SIM and SIM.R differ at the Fv-1 locus.体外对N-和B-嗜性鼠白血病病毒的遗传抗性：同基因小鼠品系SIM和SIM.R在Fv-1基因座存在差异的证据。
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10
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