Wall J D
Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA.
Mol Biol Evol. 2000 Jan;17(1):156-63. doi: 10.1093/oxfordjournals.molbev.a026228.
Three new estimators of the population recombination rate C = 4Nr are introduced. These estimators summarize the data using the number of distinct haplotypes and the estimated minimum number of recombination events, then calculate the value of C that maximizes the likelihood of obtaining the summarized data. They are compared with a number of previously proposed estimators of the recombination rate. One of the newly proposed estimators is generally better than the others for the parameter values considered here, while the three programs that calculate maximum-likelihood estimates give conflicting results.
引入了三种新的群体重组率C = 4Nr的估计方法。这些估计方法利用不同单倍型的数量和估计的最小重组事件数来汇总数据，然后计算出使获得汇总数据的可能性最大化的C值。将它们与一些先前提出的重组率估计方法进行了比较。对于这里考虑的参数值，新提出的估计方法之一通常比其他方法更好，而计算最大似然估计的三个程序给出了相互矛盾的结果。
