Fabiani G, Teive H A, Germiniani F, Sá D, Werneck L C
Hospital de Clínicas da Universidade Federal do Paraná, Brasil.
Arq Neuropsiquiatr. 1999 Sep;57(3A):610-4. doi: 10.1590/s0004-282x1999000400012.
This study aims to describe the clinical patterns and therapeutic responses in 135 patients with dystonia. According to the classification, 54% were focal; 17.8% were segmental; 8.1% hemidistonia; 18.6% generalized and 1.5% were multifocal. There was a positive familial history in 5.9% of the cases. The treatment of the idiopathic dystonias is divided in: specific and symptomatic, and it can be local with botulinum toxin, or systemic with oral drugs. The most common drugs used in the treatment were anticholinergics and benzodiazepines, with poor responses in the generalized forms. Botulinum toxin A was the first line treatment for focal and segmental forms of dystonia. Meanwhile, the generalized forms of dystonia show poor response to the therapies utilized.
本研究旨在描述135例肌张力障碍患者的临床模式和治疗反应。根据分类，54%为局灶性；17.8%为节段性；8.1%为偏侧肌张力障碍；18.6%为全身性，1.5%为多灶性。5.9%的病例有阳性家族史。特发性肌张力障碍的治疗分为：特异性和对症性治疗，可局部使用肉毒毒素，或全身使用口服药物。治疗中最常用的药物是抗胆碱能药和苯二氮䓬类药物，对全身性肌张力障碍反应较差。A型肉毒毒素是局灶性和节段性肌张力障碍的一线治疗方法。同时，全身性肌张力障碍对所采用的治疗反应较差。
