Cicalese L, Giacomoni A, Rastellini C, Benedetti E
Division of Transplant Surgery, University of Illinois, Chicago 60612, USA.
Int Surg. 1999 Oct-Dec;84(4):305-12.
Pancreatic transplantation recently became a routine treatment for Type I diabetic patients with uremia or for those who previously received a kidney transplant with 1 year graft and patient survival of over 80% and 90%, respectively. Despite the life-long need for immunosuppression, this is clearly acceptable when compared to the need for dialysis and insulin therapy, and it reduces the evolution of diabetic complications. Isolated pancreatic transplant is less commonly applied because of the need for immunosuppression and the high rate of complications. However, this can still be an acceptable option for individual patients with brittle diabetes and hypoglycemic unawareness. Despite the fact that pancreas transplantation is an effective treatment for selected Type I diabetics, it remains a difficult surgical procedure with many potential complications and with several issues still subject to debate. In this article, the authors describe the procedure in all of its aspects and variations, and offer, through a review of the recent literature, insights on the current status of this transplant
胰腺移植最近已成为患有尿毒症的I型糖尿病患者或那些先前接受过肾移植且移植肾和患者1年生存率分别超过80%和90%的患者的常规治疗方法。尽管需要终身免疫抑制，但与透析和胰岛素治疗的需求相比，这显然是可以接受的，并且它减少了糖尿病并发症的进展。单纯胰腺移植由于需要免疫抑制和并发症发生率高而较少应用。然而，对于患有脆性糖尿病和低血糖无知觉的个体患者，这仍然可能是一个可接受的选择。尽管胰腺移植是某些I型糖尿病患者的有效治疗方法，但它仍然是一种困难的外科手术，有许多潜在并发症，并且有几个问题仍存在争议。在本文中，作者描述了该手术的各个方面和变体，并通过对近期文献的综述，提供了关于这种移植现状的见解
