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Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4- dioxo-1,2,3,4-tetrahydropyrido[2,3-d]-pyrimidine-5-carboxylic acid.

作者信息

Sladowska H, Sieklucka-Dziuba M, Rajtar G, Sadowski M, Kleinrok Z

机构信息

Department of Chemistry of Drugs, Wrocław Medical University, Poland.

出版信息

Farmaco. 1999 Nov-Dec;54(11-12):773-9. doi: 10.1016/s0014-827x(99)00101-9.

DOI:10.1016/s0014-827x(99)00101-9
PMID:10668178
Abstract

Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4- tetrahydropyrido[2,3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity.

摘要

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