Sladowska H, Zawisza T
Farmaco Sci. 1986 Dec;41(12):954-63.
Amides of 1-benzyl-3,7-dimethyl-4-oxo-2-thioxo-1,2,3,4- tetrahydropyrido[2,3]pyrimidine-6-carboxylic acid were obtained by the condensation of ammonia, primary and secondary cyclic amines with the corresponding acid chloride. As by - products amides of 1-benzyl-3,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyr imidine-6- carboxylic acid were isolated as a result of desulfuration. The same reaction performed with chloride of 1-butyl-7-methyl-3-phenyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyri do[2,3- d]pyrimidine-6-carboxylic acid gave mainly the corresponding 2,4-dioxo-amides.
通过氨、伯胺和仲环胺与相应的酰氯缩合，得到了1-苄基-3,7-二甲基-4-氧代-2-硫代-1,2,3,4-四氢吡啶并[2,3]嘧啶-6-羧酸的酰胺。作为副产物，由于脱硫作用，分离出了1-苄基-3,7-二甲基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3 - d]嘧啶-6-羧酸的酰胺。用1-丁基-7-甲基-3-苯基-4-氧代-2-硫代-1,2,3,4-四氢吡啶并[2,3 - d]嘧啶-6-羧酸的酰氯进行相同反应，主要得到相应的2,4-二氧代酰胺。
